Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 18, Problem 7P
The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.
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Students have asked these similar questions
Thioester play an important role in glycolysis and the TCA cycle. Which reactions in glycolysis and tca cycle involve thioesters.
Which one of the following regarding the chemistry of glycolysis & gluconeogenesis is FALSE?
Reaction 6 of glycolysis catalyzed by glyceraldehyde-3-phosphate dehydrogenase involves oxidation & addition of a P; group.
Reaction 3 of gluconeogenesis catalyzed by enolase involves hydration, the addition of water to a carbon-carbon double bond (C=C) to form an alcohol.
Reaction 1 of gluconeogenesis catalyzed by pyruvate carboxylase involves decarboxylation.
Reaction 9 of gluconeogenesis catalyzed by fructose-1,6-bisphosphatase involves dephosphorylation (phosphoester hydrolysis).
Reaction 1 of glycolysis catalyzed by hexokinase involves phosphorylation (using ATP).
O 0000
There are eighteen (18) rows of boxes, for around 36-38 boxes total. Please see images attached. This is a pathway trace, with the final box showing "ribose 5 phosphate" as the end product.
Any help is appreciated-thank you!
glutamate to ribose 5 phosphate
No a ketoglutarate dehydrogenase
No pyruvate carboxylase
No transketolase
No transaminase
You do get to have if needed:
erythrose 4 phosphate
asparate
dihydroxyacetone phosphate
bicarbonate
ATP
ornithine
CO2
Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.arrow_forwardThe intermediates of glycolysis with a free energy of hydrolysis sufficient to couple conversion of ADP + phosphate to ATP (a substrate level phosphorylation) include (Choose all that apply) O phosphoenolpyruvate O 2-phosphoglycerate O 1,3-bisphosphoglycerate O glucose-6-phosphate. O fructose-6-phosphate. O fructose-1,6-bisphosphate. O dihydroxyacetone phosphatearrow_forwardFatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved.. give necessary detail.. avoid cpy rightingarrow_forward
- Fatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved. . give necessary details as well.. do not copyrightarrow_forwardActivation of the fatty acid (converting it to fatty acyl-SCoA) requires the expenditure of 2 ATPs. Use your answers from parts B and C to calculate the total number of ATPs generated from the metabolism of a saturated fatty acid with 18 carbon atoms including both the citric acid cycle and the ββbeta-oxidation pathway as well as the initial ATP required to produce the acyl-SCoA molecule that starts the process. Express your answer as an integer.arrow_forwardPlease choose the right answer from the bold text In the malate dehydrogenase-catalyzed reaction, L-malate is (oxidized, unaffected, reduced) to oxaloacetate. Based on their oxidation states, we know that (malate, oxaloacetate, neither) contains more free energy, and free energy will be (released, required) in the forward reaction of malate to oxaloacetate.arrow_forward
- This is the ATP accounting question. You are limited to the carbon in the following molecules: One xylulose 5-phosphate, One glyceraldehyde 3-phosphate, One sedoheptulose 7-phosphate, 1 Oxaloacetate, and 3 carbon dioxide A) Disregard regulation completely regarding pathway activity, using only the enzymes of glycolysis, pentose phosphate pathway, and citric acid cycle, what is the maximum ATP one can generate with these molecules? B) Disregard regulation completely regarding pathway activity, using only the enzymes of glycolysis, Calvin- Benson-Bassham cycle, and citric acid cycle, what is the maximum ATP one can generate with these molecules (in this instance only, you also are given 3 ATP and note that you do NOT need to regenerate substrates for rubisco once you get through this enzyme).arrow_forwardATP is an ALLOSTERIC INHIBITOR of the phosphofructokinase enzyme, which is a key catalyst for one of the first steps of Glycolysis. Citrate (citric acid) is a 6-carbon product of the first reaction of the Krebs Cycle (aka Citric Acid Cycle). Interestingly, Citrate enhances the inhibitory effect of ATP on phosphofructokinase. What is a likely explanation for the inhibitory effects of these molecules? Excess ATP and Citrate signal the cell that Glycolysis should be speeded up. Excess ATP and Citrate signal a positive feedback loop. Excess ATP and Citrate signal the cell that Glycolysis should be slowed. Excess ATP and Citrate compete for the active site of phosphofructokinase.arrow_forwardCompare and contrast Pyruvate Dehydrogenase with a-ketoglutarate dehydrogenaseOutline the mechanisms of both enzymes. Discuss the functions of the coenzymes. List the similarities and the differences between the 2 enzymes. Both are very large membrane bound complexes. What are the advantages of this strategy?Do a bit or research on the structure one of these enzymes. (include one recent reference) – How detailed is the enzyme structure known? What insight(s) does this structural detail give you about the enzyme mechanism.arrow_forward
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