Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 18, Problem 23P
Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Describe the mechanism of a-chymotrypsin. Explain the roles of constituents of the
catalytic triad, their modes of catalysis, and the significance of the oxyanion hole in the
catalysis.
Order the cofactors based on their use in the mechanism of the a-etogluterate dehydrogenase complex.
1. Stabilizes a carbanion due to decarboxylation
2. Allows for the splitting of the carbon skeleton from the electron pair generated in a redox reaction
3. Enzyme bond electron carrier that is part of dihydrolipoyl dehydrogenase
4. Final electron acceptor in the overall reaction catalyzed by this complex
1
2
3
4
answer choices: lipoamide, biotin, 2 Fe - 2S cluster, TPP, NAD+, FAD
Propose a metabolic I pathway for methotrexate
Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.arrow_forwardExtending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.arrow_forwardOrder the cofactors based on their use in the mechanism of the a-ketogluterate dehydrogenase complex. 1. Stabilizes a carbanion due to decarboxylation 2. Allows for the splitting of the carbon skeleton from the electron pair generated in a redox reaction 3. Enzyme bond electron carrier that is part of dihydrolipoyl dehydrogenase 4. Final electron acceptor in the overall reaction catalyzed by this complex 1 (Choose ] [Choose ] FAD Lipoamide 2 Fe 2S cluster TPP Biotin 3. NAD+ 4 [Choose ] 2.arrow_forward
- Write out the balanced chemical equation for the FIRST round of oxidation of C16:cis-9.arrow_forwardOne mechanism by which lead exerts its poisonous effect on enzymes can be stopped by chelation therapy with EDTA. Describe this type of lead poisoning and explain why it is reversible.arrow_forwardWrite a balanced equation for the reaction catalyzed bynitrogenase.arrow_forward
- Refer to Figure, which indicates ∆G for each glycolytic reaction under intracellular conditions. Assume that glyceraldehyde-3-phosphate dehydrogenase was inhibited with iodoacetate, which reacts with its active site cysteine sulfhydryl group. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?arrow_forwardShow the carbon atom that changes oxidation state during the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase. What is the functional group that changes during the reaction?arrow_forwardDraw the products of the reaction of xylulose-5-phosphate and erythrose-4-phosphate catalyzed by transketolase in the pentose phosphate pathway. Provide the structure in the protonation state found in physiological conditions. H H H OH FO HO-H H-OH H OPO3²- Q transketolase Draw glyceraldehyde-3- phosphate H H- H H H O OH OH OPO3²- Draw fructose-6- phosphate Q I Iarrow_forward
- Using the principles described in the text regarding pyridoxal phosphate mechanisms, propose a mechanism for the reaction catalyzed by serine hydroxymethyltransferase.arrow_forwardDescribe the alcohol dehydrogenases of humans and S. cerevisiae. How do they differ?arrow_forwardExplain biochemical pathways mechanistically. Describe the β-oxidation pathway. Describe the conversion of propionyl CoA to succinyl CoA. Describe the substrate activation processes in the urea cycle (CPS 1 and arginosuccinate synthetase).arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY