(a)
Interpretation: The Given compounds can be prepared using a Reformatsky reaction has to be described.
Concept introduction: An
On acidic hydrolysis of ester, the
(b)
Interpretation: The Given compounds can be prepared using a Reformatsky reaction has to be described.
Concept introduction: An aldehyde or ketone is reacted with an organozinc reagent. The organozinc reagent is added to the carbonyl of aldehyde. The final product on hydrolysis is required
On acidic hydrolysis of ester, the carboxylic acid can be obtained. To remove a molecule of water, the
(c)
Interpretation: The Given compounds can be prepared using a Reformatsky reaction has to be described.
Concept introduction: An aldehyde or ketone is reacted with an organozinc reagent. The organozinc reagent is added to the carbonyl of aldehyde. The final product on hydrolysis is required
On acidic hydrolysis of ester, the carboxylic acid can be obtained. To remove a molecule of water, the
(d)
Interpretation: The Given compounds can be prepared using a Reformatsky reaction has to be described.
Concept introduction: An aldehyde or ketone is reacted with an organozinc reagent. The organozinc reagent is added to the carbonyl of aldehyde. The final product on hydrolysis is required
On acidic hydrolysis of ester, the carboxylic acid can be obtained. To remove a molecule of water, the
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Organic Chemistry
- Define the mechanism for the reaction between an ester and a grignard reagent ?arrow_forwardPrepare the following compounds starting from benzaldehyde and the appropriate ketone. Provide reactions for preparing the ketones starting from aromatic hydrocarbon compounds.arrow_forwardThe Reformatsky reaction is an addition reaction in which an organozinc reagent is used instead of a Grignard reagent to add to the carbonyl group ofan aldehyde or a ketone. Because the organozinc reagent is less reactive than a Grignard reagent, a nucleophilic addition to the ester group does not occur.The organozinc reagent is prepared by treating an a-bromo ester with zinc. Describe how each of the following compounds can be prepared, using a Reformatsky reaction:arrow_forward
- describe how steric and electronic effects influence the postion of equilibrium when the electrophilic center of an aldehyde or ketone is under nucleophilic attack.arrow_forwardWhat explains why many aldehydes and ketones can undergo self- condensation reactions in basic conditions? The alpha carbon can lose a proton and act like a nucleophile and the carbonyl carbon a an electrophile O The alpha carbon can gain a proton and act like an electrophile and the carbonyl carbon is a nucleophile O The oxygen of the carbonyl group can attack the carbon of the carbonyl group Only esters can undergo self-condensation reactionsarrow_forwardThe following molecule can be formed via an intramolecular aldol addition reaction. Draw the organic starting material needed to form the given B-hydroxycarbonyl compound. organic starting material B-hydroxycarbonyl NaOH OHarrow_forward
- Choose the best reagents to complete the following reactions.arrow_forwardA ketone can be prepared from the reaction of a nitrile with a Grignard reagent. Describe the intermediate formed in this reaction, and show how it can be converted to a ketone.arrow_forwardFor the following reaction schemes, fill in the appropriate reagents and starting materials you would use to transform the acetoacetic ester and acetone into nabumetone, an NSAID drug used for arthritis and joint pain. Write the correct reagents/reactants next to the number of steps for each transformation.arrow_forward
- base 2 H3C H H3C OH heat H H3C + H₂O H The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a ẞ-hydroxy carbonyl compound. Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the ẞ-hydroxyl group is eliminated in an E1CB dehydration to give an a,ẞ-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions X :OH H₂O: а کی H₂C H H₂C H Harrow_forwardIdentify the best reagents to complete the following reaction.arrow_forwardDrawing an Enol and a Ketone Formed by Hydration of an Alkyne Draw the enol intermediate and the ketone product formed in the following reaction.arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning