Organic Chemistry
Organic Chemistry
6th Edition
ISBN: 9781936221349
Author: Marc Loudon, Jim Parise
Publisher: W. H. Freeman
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Chapter 25, Problem 25.38AP
Interpretation Introduction

Interpretation:

It is to be explained how the G0 for the hydrolysis of acetyl-CoA would change if the hydrolysis were carried out at pH=11

Concept Introduction:

At pH=7, hydrolysis can proceed with water. But, water is not a very good nucleophile. At pH=11, the reaction medium is basic. Hydroxide ion is present, which is a reactive nucleophile as compared to water.

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