(a) The evidence that suggests that the evolution of the drug-resistant strain of the bacterium happened within the patient. (b) The fitness rate of the rpoB (Beta subunit of ribose nucleic acid polymerase) gene in the environment due to the banning of the rifampin antibiotic. Introduction: Tuberculosis is a disease of the respiratory tract that is caused by Mycobacterium tuberculosis . A patient with tuberculosis was treated with rifampin antibiotic and the infection was cleared in 10 months. Two months later, the patient was readmitted and was treated with a variety of different antibiotics including rifampin, but dies because of respiratory failure because the antibiotic was not effective on the mutant bacteria mutated for rpoB gene. The nucleotide sequence of the bacteria before and after the treatment was analyzed.

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Chapter 25, Problem 11TYU

Summary Introduction

To review:

(a) The evidence that suggests that the evolution of the drug-resistant strain of the bacterium happened within the patient.

(b) The fitness rate of the rpoB (Beta subunit of ribose nucleic acid polymerase) gene in the environment due to the banning of the rifampin antibiotic.

Introduction:

Tuberculosis is a disease of the respiratory tract that is caused by Mycobacterium tuberculosis. A patient with tuberculosis was treated with rifampin antibiotic and the infection was cleared in 10 months. Two months later, the patient was readmitted and was treated with a variety of different antibiotics including rifampin, but dies because of respiratory failure because the antibiotic was not effective on the mutant bacteria mutated for rpoB gene. The nucleotide sequence of the bacteria before and after the treatment was analyzed.

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