Study Guide for Campbell Biology
Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 9, Problem 22TYK

Brown fat, which is found in newborn infants and hibernating mammals, has uncoupler proteins that, when activated, make the inner mitochondrial membrane leaky to H+. What is the function of brown fat?

  1. a. It produces more ATP than does regular fat and is also found in the flight muscles of ducks and geese, providing more energy for long-distance migrations.
  2. b. It lowers the pH of the intermembrane space, which results in the production of more ATP per gram than is produced by the oxidation of glucose or regular fat tissue.
  3. c. Because it dissipates the proton gradient, it generates heat through cellular respiration without producing ATP, thereby raising the body temperature of hibernating mammals or newborn infants.
  4. d. Its main function is insulation in the endothermic animals in which is it common.
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When the chemical dinitrophenol (DNP) is added to mitochondria, the inner membrane becomes permeable to protons. When the drug valinomycin is added to mitochondria, the inner membrane becomes permeable to potassium ions (K+). A. How will the electrochemical proton gradient change in response to DNP?     B. How will it change in response to valinomycin?
The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?
What would be the effect on ATP production of decreasing the pH inside the mitochondrial matrix? Explain

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Study Guide for Campbell Biology

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY