Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 22.5, Problem 1COMQ
A means of introducing a cloned gene into cells for gene therapy is via
a. liposomes.
b. retroviral vectors.
c. T-DNA vectors.
d. both a and b.
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Which of the following is a concern of in-vivo gene therapy?
A. Lytic vector expression
B. Integration into target region
C. Immune response to viral vector
D. Production of chimera
Which of the following best describes the approach that wasused in the first gene therapy trial for treating SCID?a. The normal ADA gene was introduced by injecting liposomesdirectly into the patients’ bodies. b. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes vialiposomes,and then the lymphocytes were returned to thepatient’s body.c. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes via a retrovirus,and then the lymphocytes were returned to thepatient’s body.d. None of the above describe the approach used in the trial.
. a. Compare the means by which retroviral and AAVvectors deliver therapeutic genes to human cells.b. Explain the advantages and disadvantages of eachof the two viral vectors.
Chapter 22 Solutions
Genetics: Analysis and Principles
Ch. 22.1 - 1. Which of the following uses of microorganisms...Ch. 22.1 - Prob. 2COMQCh. 22.1 - Prob. 3COMQCh. 22.2 - When a cloned gene is inserted into a noncritical...Ch. 22.2 - Prob. 2COMQCh. 22.3 - Prob. 1COMQCh. 22.3 - Prob. 2COMQCh. 22.4 - Prob. 1COMQCh. 22.4 - Prob. 2COMQCh. 22.5 - A means of introducing a cloned gene into cells...
Ch. 22.5 - 2. Which of the following best describes the...Ch. 22 - 1. What is a recombinant microorganism? Discuss...Ch. 22 - Prob. 2CONQCh. 22 - 3. What is bioremediation? What is the difference...Ch. 22 - Prob. 4CONQCh. 22 - Prob. 5CONQCh. 22 - Prob. 6CONQCh. 22 - 7. What is a transgenic organism? Describe three...Ch. 22 - Prob. 8CONQCh. 22 - Explain the difference between gene modification...Ch. 22 - As described inChapter 5, not all inherited traits...Ch. 22 - Prob. 11CONQCh. 22 - 12. Discuss the concerns that some people have...Ch. 22 - Prob. 1EQCh. 22 - 2. Bacillus thuringiensis makes toxins that kill...Ch. 22 - Prob. 3EQCh. 22 - Prob. 4EQCh. 22 - Prob. 5EQCh. 22 - What is a gene knockout? Is an animal or plant...Ch. 22 - Prob. 7EQCh. 22 - Evidence [see P. G. Shiels, A. J. Kind, K. H....Ch. 22 - Prob. 9EQCh. 22 - 10. What is reproductive cloning? Are identical...Ch. 22 - Researchers have identified a gene in humans that...Ch. 22 - Treatment of adenosine deaminase (ADA) deficiency...Ch. 22 - Several research studies are under way that...Ch. 22 - Prob. 1QSDCCh. 22 - 2. A commercially available strain of P....Ch. 22 - Prob. 3QSDC
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- Which of the following is correct regarding the vector vaccine? Select one: a. It is a vaccine which uses a non-pathogenic virus to introduce pieces of the pathogen to the host b. It is a vaccine which is made by killed pathogen c It is a vaccine which is not alive but uses cloned genes from the pathogen in a vector d. It is a vacciñe which is considered as an attenuated vaccine but carries the pathogen genes in a vector e It doesn't need cloning stepsarrow_forwardGive a schematic diagram of how we can Treatment Hemophilia by using gene therapy? Please answer at your own words,please..arrow_forwardWhy are vaccines and/or passive immunization the method of choice in the treatment or prevention of viral infections? A. There are no known inhibitors to reverse transcription B. Viruses are non-living and do not have their own genetic mechanisms to reproduce by themselves hence host cells must rely on targeting the virus or their products. C. Antibodies prevent replication of viral genome D. Antibodies prevent transcription and translation of viral genomes E. All of thesearrow_forward
- D) RNA polymerase 29. In lecture, we discussed some of the new platforms for COVID-19 vaccines. Adenovirus-vector vaccines and mRNA vaccines both involve the introduction of pieces of DNA or RNA, respectively. In both cases, the objective is to ... A) enable the human body to produce the SARS-coV-2 genome. B) enable the human body to produce the SARS-coV-2 spike protein. C) inhibit viral polymerase. D) inhibit neuraminidase. E) inhibit reverse transcriptase.arrow_forwardWhich of the following best describes the mechanism of action of the antibiotic streptomycin? A. it disrupts protein synthesis in resistant bacteria. B. Streptomycin inhibits cell wall synthesis in all bacterial species. C. Streptomycin creates mutations in bacteria which cause them to become resistant. D. It disrupts protein synthesis in nonresistant bacteria.arrow_forwardImmunofluorescence and GPF tagging are most commonly used to... a. localize proteins within a cell or organism. b. localize mRNA inside a cell or organism. c. deduce the function of specific genes within an organism. d. follow a signal transduction pathway within a cell or organism.arrow_forward
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