3. Researchers are investigating a newly discovered condition that greatly increases the likelihood of lung damage associated with the use of e-cigarettes. They found that 2% of their study population has the condition. The researchers believe they have found a useful marker locus for assessing the presence of the condition in individuals with unknown family history. They have found that, of those individuals with the condition, 99% have the marker allele M1. Of those without the condition, 99.8% have an alternative allele M2 at the marker locus. What is the probability that an individual has the condition if they have marker allele M1 and what do you conclude about the utility of the marker locus for indirect diagnosis?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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3. Researchers are investigating a newly discovered condition that greatly increases the likelihood of lung damage associated with the use of e-cigarettes. They found that 2% of their study population has the condition. The researchers believe they have found a useful marker locus for assessing the presence of the condition in individuals with unknown family history. They have found that, of those individuals with the condition, 99% have the marker allele M1. Of those without the condition, 99.8% have an alternative allele M2 at the marker locus. What is the probability that an individual has the condition if they have marker allele M1 and what do you conclude about the utility of the marker locus for indirect diagnosis?

 

4) Consider the pedigree below. Double lines indicate matings between related individuals:
P1
2
F1
3
F2
6
8
10
F3
11
(12
13
(14
15
a) Calculate the inbreeding coefficient of individual 10 assuming none of their common ancestors
are themselves inbred.
b) Calculate the inbreeding coefficient of individual 15 assuming findividuall = 0.05.
Transcribed Image Text:4) Consider the pedigree below. Double lines indicate matings between related individuals: P1 2 F1 3 F2 6 8 10 F3 11 (12 13 (14 15 a) Calculate the inbreeding coefficient of individual 10 assuming none of their common ancestors are themselves inbred. b) Calculate the inbreeding coefficient of individual 15 assuming findividuall = 0.05.
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