2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from atoothbrush of a potential victim had the genotype A1A4B2B3C4C5D¡D1. Remains from an unidentifiedvictim were found to have the same genotype. Given the allele frequencies in the relevant population inthe table below:a) What is the probability that these two samples matches by chance?b) List two assumptions you made in answering this question.LocusalleleACD10.20.10.150.720.10.60.10.330.050.10.140.250.050.350.400.150.35 1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlosdisease. The pedigree covers three generations of a particular family and also shows individualgenotypes at a potential marker locus (M).a) Indicate the phase of all gen II and III individuals.DdM1M3ddM2M6IIDDM3M6ddM4M5IIIDdMзM4 DdMЗМ5DDM3M4ddM3M5DDM3M4ddM5M6DDM3M4ddM4M6ddM5M6ddM5M6b) Which, if any, of the gen III individuals are recombinants?c) Calculate the LOD score as a test of physical linkage between the marker (M) and the diseaselocus.d) What do you conclude about linkage between D and M?

Hi, Thanks For Your Question. Q. 2 Answer :

2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A¡A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C 1 0.2 0.1 0.15 0.7 0.1 0.1 0.1 0.6 0.3 0.05 0.1 0.25 0.05 0.3 0.40 0.15 0.35 N345

2. DNA profiles can be used to identify unknown victims from a natural disaster. A DNA sample from a toothbrush of a potential victim had the genotype A¡A4B2B3C4C5D¡D1. Remains from an unidentified victim were found to have the same genotype. Given the allele frequencies in the relevant population in the table below: a) What is the probability that these two samples matches by chance? b) List two assumptions you made in answering this question. Locus allele A C 1 0.2 0.1 0.15 0.7 0.1 0.1 0.1 0.6 0.3 0.05 0.1 0.25 0.05 0.3 0.40 0.15 0.35 N345

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male Carrier
II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant and b) X-linked recessive in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I || III 1 1 2 a) X-linked recessive 9 III 6 genotype (circle one): XX * 1 2 3 11x12 4 ΧΑΧΑ 2 5 xaxa *4 6 7 8 b) X-linked dominant 11 x 12 오 XAX хах
1. Please consider the following pedigree. I 1 2 II 1 a) Assume that colour is controlled by a single sex-influenced gene where orange is expressed preferentially in females. Individuals I-1 and I-2 are homozygous for orange and blue respectively. Which individual/s in generation II will be blue? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be orange?
II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) Autosomal recessive and b) Autosomal dominant in order to determine what is the mode of transmission of this trait. Disease allele = a or A, depending on mode of transmission of the disease respectively. Your Punnett squares should reflect what you see in generation II. Circle the mode of transmission. Note: Observe the whole pedigree. I Circle the mode of transmission 1 III 6 genotype (circle one): AA Created by Dr. Susan A. Holechek for BIO 340 (2023) 2 1 2 3 4 a) Autosomal recessive 11 x 12 9 XªXa 2 3 5 6 Ở хаха *4 7 b) Autosomal dominant 11x12 8 Aa *Unaffected/No carrier-Normal AaAa
6) For the pedigree shown below, answer the following questions. I II III a) What type of inheritance is shown? Explain how you know. b) The genotype of individual I -2 is The genotype of individual II -1 is
1. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked recessive and b) X-linked dominant in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xa, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I 11 * 1 2 1 2 3 a) X-linked recessive 11x12 III 2 genotype (circle one): XY 4 XAXA 2 3 5 Xaya *4 6 7 8 b) X-linked dominant 11x12 XAY Xay
2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.
1. Please consider the following pedigree. I 1 II 1 a) Assume that colour is controlled by a single sex-influenced gene where green is expressed preferentially in males. Individuals I-1 and I-2 are homozygous for red and green respectively. Which individual/s in generation II will be red? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be green?
Ensure answers are clearly labelled a) & b). a) Consider the following pedigree. The solid symbols represent affected individuals. Which of the following is / are possible genotypes for II-2 with respect to this disease? Please type 1 - 4, and indicate yes or no only for each. II III 1. xAxa 2. xaxa 3. Aa 4. AA2 b) Genes A, B and C are on the same chromosome linked in cis (coupling) conformation. A'is 16 cM from B, and B is 22 cM from C. The distance between A and C is 38 cM. The coefficient of coincidence is 0.55 for a trihybrid test cross. How many individuals with the genotype AabbCc do you expect to see among the offspring of the cross if 1000 offspring are obtained? Please show your calculations and round your answer off to the nearest whole number.
Ensure answers are clearly labelled a) & b). a) Consider the following pedigree. The solid symbols represent affected individuals. Which of the following is / are possible genotypes for IV-2 with respect to this disease? Please type 1 - 4, and indicate yes or no only for each I II III 1 IV 3 V 1 1. ХАха 2. хаха 3. Aa 4. A1Α2 b) Genes A, B and C are on the same chromosome linked in cis (coupling) conformation. A is 23 cM from B, and B is 17 cM from C. The distance between A and C is 40 cM. The coefficient of coincidence is 0.75 for a trihybrid test cross. How many individuals with the genotype aaBbcc do you expect to see among the offspring of the cross if 1000 offspring are obtained? Please show your calculations and round your answer off to the nearest whole number.
10. Examine the pedigree from a family with a genetic disease and answer the questions below: 1:1 1:2 I1:1 II:2 I1:3 Il:4 II:5 I1:6 II:1 III:2 II:3 I:4 III:5 II:6 a) Does this pedigree indicate autosomal dominant, recessive or sex- linked type of inheritance? Give reasons for your choice. b) Assuming that B and b are the normal and mutant alleles respectively, what would be the genotypes of the individuals: II.1, II.2 and III.3 ? c) Individual II.3 requested genetic counselling. What is the probability that her child would be affected. Explain why.
There are six types of agglutinogen named C,D, E and c,d,e.the first three are dominant and last three are recessive.discuss