1. What is a translocation? Give an example of a translocation associated with a genetic condition in humans.
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Week 8 Q1
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- Name the type of translocations and explain their mechanism of occurrence.Discuss the following types of mutations, with reference to specific genetic disorders: i) Chromosomal deletion; ii) Reciprocal translocation; and iii) HaploinsufficiencyExplain how it is possible for a person with a translocationor an inversion to be phenotypically normal.
- Robertsonian translocation is balanced or unbalanced?3. An inversion heterozygote has the following inverted chromosome: Centromere )))))))))))) A B JI HGF ED CKLM Inverted region What would be the products if a crossover occurred between the genes F and E on the inverted chromosome and the normal chromosome?How do translocations in which no genetic information is lost or gained produce phenotypic effects?
- Why is it more efficient to perform a test cross with a homozygous recessive donor than a homozygous dominant donor? How could the same information still he found with a homozygous dominant donor?A geneticist discovers that a girl with Down syndrome has a Robertsonian translocation involving chromosomes 14 and 21. If she has an older brother who is phenotypically normal, what are the chances that he is a translocation carrier?What are some physical appearances of individuals affected by the abnormality structure of deletion, inversion, duplication, and translocation?