. Intracellular concentrations in resting muscle are as follows: fructose- 6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM; ADP, 0.5 mM; ATP, 5 mM; and P;, 10 mM. Is the phosphofruc- tokinase reaction in muscle more or less exergonic than under stan- dard conditions? By how much?
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- Intracellular concentrations in resting muscle are as follows: fructose6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM;ADP, 0.5 mM; ATP, 5 mM; and Pi, 10 mM. Is the phosphofructokinasereaction in muscle more or less exergonic than under standard conditions?By how much?Intracellular concentrations in resting muscle are as follows: fructose- 6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM; ADP, 0.5 mM; ATP, 5 mM; and P, 10 mM. Is the phosphofructokinase reac- tion in muscle more or less exergonic than under standard conditions? By how much?is this stement false? Intracellular concentrations in resting muscle are as follows: Fructose-6-phosphate (1.0 mM)Fructose-(1-6)-bisphosphate (10.0 mM)AMP (0.1 mM)ADP (0.5 mM)ATP (5.0 mM)Pi (10.0 mM)Under the above conditions the Phosphofructokinase reaction in muscle is more exergonic than under standard conditions.
- Calculate glucose concentration. Na (sodium) and glucose secondary active transport. Na transport (which drive glucose import) G=R*T*In(Na in/ Na out)+Z*F*Y(psi symbol) Na in=14mM Na out=145MM Z=+1 F=96.5 KJ/V*mol Y(psi)=-0.05V What is the glucose in and out concentration? Please be very through when explaining this calculation. (I am stuck at why the energy sign changes from negative to positive when using the calculated energy from sodium to glucose).Intramitochondrial ATP concentrations are about 5 mM, and phosphate con- centration is about 10 mM. If ADP is five times more abundant than AMP, calculate the molar concentrations of ADP and AMP at an energy charge of 0.85. Calculate AG for ATP hydrolysis at 37 °C under these conditions. The energy charge is the concentration of ATP plus half the concentration of ADP divided by the total adenine nucleotide concentration: [ATP] + 1/2[ADP] [ATP] + [ADP] + [AMP]A sprinter would experience muscle fatigue sooner than a marathon runner due to ________. anaerobic metabolism in the muscles of the splinter anaerobic metabolism in the muscles of the marathon runner aerobic metabolism in die muscles of the sprinter glycolysis in the muscles of the marathon runner
- Kt of glucose for GLUT1=3 mM, GLUT2=17 mM, GLUT 3=1.3 mM, and GLUT11=0.3 mM. Sketch a graph with [glucose] on the x-axis and rate of transport on the y-axis. Sketch a line for each GLUT transporter above. Which of these GLUT transporters will be working at its maximum rate at [glucose]=5 mM? Which of these GLUT transporters will be working closest to ½ Vmaxwhen [glucose]=5 mM? What will be the approximate rate of glucose transport for each of these transporters if [glucose]=17 mM?Since ancient times it has been observed that certain game birds, such as grouse, quail, and pheasants, are easily fatigued. The Greek historian Xenophon wrote: “The bustards . . . can be caught if one is quick in starting them up, for they will fly only a short distance, like partridges, and soon tire; and their flesh is delicious.” The flight muscles of game birds rely almost entirely on the use of glucose 1-phosphate for energy, in the form of ATP . The glucose 1-phosphate is formed by the breakdown of stored muscle glycogen, catalyzed by the enzyme glycogen phosphorylase. The rate of ATP production is limited by the rate at which glycogen can be broken down. During a “panic flight,” the game bird’s rate ofglycogen breakdown is quite high, approximately 120 mmol/min of glucose 1-phosphate produced per gram of fresh tissue. Given that the flight muscles usually contain about 0.35% glycogen by weight, calculate how long a game bird can fly. (Assume the average molecular weight of a…Which of the following is the correct summary of the anaerobic breakdown of glucose in the skeletal muscle? Glucose + ADP + Pi ⟶ lactate + ATP Glucose + 2ADP + 2Pi ⟶ 2 lactate + 2ATP Glucose + 2ADP + 2Pi + 2NAD+ ⟶ 2 pyruvate + 2ATP + 2NADH + 2H+ Glucose + ADP + Pi ⟶ pyruvate + ATP Glucose + 2ADP + 2Pi ⟶ 2 pyruvate + 2ATP
- decrease in *The following reaction occurs during the glycolysis pathway: glucose-6-phosphate a) b) AG°¹ fructose-6-phosphate +0.4 kcal/mol Determine the value for the equilibrium constant in a mammal whose body temperature is 37°C. In red blood cells, normal observed cellular concentrations include 83 μM glucose-6-phosphate, and 14 μM fructose-6- phosphate. Under these conditions, is this reaction at equilibrium? If not, will it favor formation of more fructose-6-phosphate or more glucose-6-phosphate? What structural feature do NAD+ NADP+ and FAD have in common?Walking consumes approximately 100 kcal/mi. In the hydrolysis of ATP (ATP → ADP + Pi), the reaction that drives muscle contraction, ΔG°′ is −7.3 kcal/mol (−30.5 kJ/mol). Calculate how many grams of ATP must be produced to walk a mile. ATP synthesis is coupled to the oxidation of glucose (ΔG°′ = −686 kcal/mol). How many grams of glucose are actually metabolized to produce this amount of ATP? (Assume that only glucose oxidation is used to generate ATP and that 40% of the energy generated from this process is used to phosphorylate ADP. The gram molecular weight of glucose is 180 g and that of ATP is 507 g.)Calculate the ATP yield for the full catabolism of a phospholipid containing ethanolamine, C18:3 Δ9, 12, 15 and oleic acid. Include any ATP “expenses” or “income”. This will be a complex problem—neatly show your work and justify your choices.