Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Textbook Question
Chapter 4, Problem 3QP
Pedigree Analysis Is a Basic Method in Human Genetics
Using the pedigree provided, answer the following questions.
- a. Is the proband male or female?
- b. Is the grandfather of the proband affected?
- c. How many siblings does the proband have, and where is he or she in the birth order?
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You are a genetic counselor, and you received the following pedigree to analyze. You must determine the following:
a. Predict the mode of inheritance of the genetic disease seen in this family. Explain why you think this.
Help me create a pedigree of this information:
Pedigree analysis:
Generation 1: Normal parents (AA x AA)
Generation 2: Carrier parents (AA x AS)
Generation 3: Affected child (AS x AS)
Generation 4: Affected grandchild (SS)
This pedigree has two normal parents in the first generation. Second generation carriers carry the sickle cell trait from one parent. The disease is 25% more likely to be inherited in the third generation if both parents have the 'S' allele. If both parents have the 'S' allele, their children will have sickle cell anemia in the fourth generation
Given the pedigree below, answer the questions that follow: (see attached image)
a. Give probable mode of inheritance. Justify
b. Genotypes
Generation
Individual
Genotype
I
1
2
II
1
2
3
4
5
6
7
III
1
2
3
4
5
6
7
C. If the proband (III-2) marries a carrier woman, what is the probability that they will have an affected son?affected daughter?
Chapter 4 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 4.3 - Does a pedigree drawn from the available...Ch. 4.3 - Prob. 2EGCh. 4.7 - Did the fact that Prince Albert and Queen Victoria...Ch. 4.7 - Which members of the pedigree could have been...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree analysis is a fundamental tool for...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Pedigree Analysis Is a Basic Method in Human...
Ch. 4 - Pedigree Analysis Is a Basic Method in Human...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Use the following information to respond to the...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - A proband female with an unidentified disease...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Prob. 12QPCh. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 16QPCh. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of Autosomal Recessive and Dominant...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Analysis of X-Linked Dominant and Recessive Traits...Ch. 4 - Prob. 23QPCh. 4 - Prob. 24QPCh. 4 - Variations in Phenotype Expression Define...Ch. 4 - Prob. 26QPCh. 4 - Variations in Phenotype Expression A genetic...Ch. 4 - Variations in Phenotype Expression Explain how...
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forward
- A. Identify the pattern of inheritance in the pedigree below. B. Provide two pieces of evidence that you used to come to this conclusion. C. Identify the genotypes of individuals II-1 and III-2 (at the arrows)arrow_forwardNon-Mendalian Genetics Answer the given with solution. Multiple Alleles: Sol is blood type AB and Luna is blood B, what are the odds that they will have a blood type AB child? How about A or B? Is O possible?arrow_forwardBased upon the above pedigree, How is this trait inherited. Please give specific evidence by identifying each generation by roman numeral, each person within that generation numerically, and stating which individuals support your claim. Look CAREFULLY!arrow_forward
- Look at the pedigree below and answer the following questions related to the human genetic trait depicted in this pedigree. 1. Indicate whether the pattern of inheritance associated with this human trait is most likely to be (i) rare X-linked recessive, (ii) sex-influenced, or (iii) sex-limited. You may assume that the gene is fully penetrant. Then, provide a specific reason that justifies your selection of this pattern of inheritance as the correct one, and also explain why each of the other two alternatives are not correct. As part of your answer, include the phenotypic ratio, including the sex of the offspring, that you would expect to find in each of the three possible scenarios.arrow_forwardA breeder is interested in a new coat colour in mice. This trait is controlled by a single autosomal gene (Gene T) with two alleles. The T-allele results in a yellow coat colour, while the recessive allele causes a cream coat colour. The breeder has a yellow mouse. Can you suggest how the breeder can determine the genotype (TT or Tt) of his mouse in a single cross? Describe this cross and provide details on how you would interpret the results.arrow_forwardWhat are the techniques in solving pedigree problems?arrow_forward
- 1:1 1:2 II:1 I1:2 I1:3 I1:4 I1:5 I1:6 III:1 III:2 IlII:3 Ill:4 III:5 III:6arrow_forwardThe pedigree below represents a disease that is very rare in the human population. Answer the two questions below. A ? a.) What is the mode of inheritance? b.) What is the probability that the child indicated with "A" will inherit the disease? Show you work for this question.arrow_forwardPedigree Analysis Assume that a sibling sought your advice as a Proband. Acting as a genetic counselor for your own family, complete the following: Scenario: Your Grandmother has a diabetes and the oldest brother of your mother is diabetic. Create a pedigree tree that will show the inheritance pattern of a specific trait in at least 4 generations of your own family. Follow standard rules and symbols in constructing the pedigree. Analyze the inheritance mechanism behind the trait, and address possible concerns that your family members may want to know. (Note: You may consult OMIM for details).arrow_forward
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