Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 4, Problem 21RQ
Summary Introduction
To compare: The energy yield from the breakdown of a glucose molecule in aerobic and anaerobic conditions
Introduction: The
Summary Introduction
To determine: The advantage of aerobic and anaerobic pathway for breakdown of glucose molecule.
Introduction: The process of glycolysis is a process which takes place by a series of enzymatically catalyzed reactions. There is a production of energy in the form of ATP at the end of the process.
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The overall reactions for gluconeogenesis and glycolysis are given below. What is the energy cost (in
ATP equivalents) of transforming one molecule of glucose to pyruvate (via glycolysis) and back to
glucose (via gluconeogenesis)?
Gluconeogenesis:
2 pyruvate + 4 ATP + 2 GTP + 2NADH + 4H₂O
Glycolysis:
Glucose + 2ADP + 2P₁ + 2NAD+ - 2 pyruvate + 2ATP + 2NADH + 2H+ + 2H₂000
Select one:
O a. 2 ATP
O b. 4 ATP
O c. 6 ATP
O d. 8 ATP
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glucose + 4ADP + 2GDP + 2P₁ +
2NAD+ + 2H+
MI
21 22
00:508D DAD
1=1
SE
30: DONDOK
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G
Which of the following is a correct ranking of molecules with respect to their energy value in glycolysis (note: >means “greater than”)? (a) two pyruvates > one glucose (b) one glucose > one fructose-1,6-bisphosphate (c) twoglyceraldehyde-3-phosphates (G3P) > one glucose (d) two pyruvates > one fructose-1,6-bisphosphate (e) two pyruvates > two glyceraldehyde-3-phosphates (G3P)
During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step? Select one:
a.
Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into the cytosol.
b.
Formation of phosphoenolpyruvate requires both ATP and GTP as an energy source.
c.
Acetyl CoA is an activator of enzyme pyruvate carboxylase.
d.
This reaction involves two-step process catalyzed by pyruvate carboxylase and phosphoenolpyruvate carboxykinase
Chapter 4 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 4.1 - Which biomolecules always include nitrogen in...Ch. 4.1 - Prob. 2CCCh. 4.1 - What is the difference between potential energy...Ch. 4.1 - Prob. 4CCCh. 4.2 - Prob. 5CCCh. 4.2 - Prob. 6CCCh. 4.2 - Prob. 7CCCh. 4.3 - Prob. 8CCCh. 4.3 - Prob. 9CCCh. 4.3 - Prob. 10CC
Ch. 4.3 - Prob. 11CCCh. 4.4 - Name five ways in which cells regulate the...Ch. 4.4 - Prob. 13CCCh. 4.4 - Prob. 14CCCh. 4.4 - Match each component on the left to the...Ch. 4.4 - Prob. 16CCCh. 4.4 - How is the separation of mitochondria into two...Ch. 4.4 - Prob. 18CCCh. 4.4 - Prob. 19CCCh. 4.4 - Prob. 20CCCh. 4.4 - What does the name RNA polymerase tell you about...Ch. 4.4 - Explain in one or two sentences the relationship...Ch. 4.4 - Prob. 23CCCh. 4.4 - List three general types of posttranslational...Ch. 4.4 - Prob. 25CCCh. 4 - List the three basic forms of work and give a...Ch. 4 - Prob. 2RQCh. 4 - Prob. 3RQCh. 4 - Prob. 4RQCh. 4 - Prob. 5RQCh. 4 - Prob. 6RQCh. 4 - Match each definition in the left column with the...Ch. 4 - Prob. 8RQCh. 4 - Organic molecules that must be present in order...Ch. 4 - In an oxidation-reduction reaction, in which...Ch. 4 - Prob. 11RQCh. 4 - Prob. 12RQCh. 4 - Prob. 13RQCh. 4 - Metabolic regulation in which the last product of...Ch. 4 - Prob. 15RQCh. 4 - Prob. 16RQCh. 4 - Create maps using the following terms.Ch. 4 - Prob. 18RQCh. 4 - Prob. 19RQCh. 4 - Prob. 20RQCh. 4 - Prob. 21RQCh. 4 - Briefly describe the processes of transcription...Ch. 4 - On what molecule does the anticodon appear?...Ch. 4 - Is the energy of ATPs phosphate bond an example of...Ch. 4 - Prob. 25RQCh. 4 - Prob. 26RQCh. 4 - Prob. 27RQCh. 4 - Prob. 28RQ
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- During the metabolism of glucose in anaerobic cells, the enzyme lactate dehydrogenase is essential to allow glycolysis to continue. This enzyme catalyzes the reduction of pyruvate to lactate. Why is this so essential? OA) It lowers the pH. B) It re-oxidizes NADH to NAD+. C) Lactate stimulates hexokinase activity. D) Pyruvate inhibits pyruvate kinase.arrow_forwardHow many ATP are produced from a triglyceride containing three 14 carbon fatty acids? NOTE: Assume that glycerol is converted to Glyceraldehyde-3-Phosphate (step 6 of glycolysis).arrow_forwardIn the Cori cycle, the lactate product of glycolysis in muscle is transformedback into glucose by the liver. (a) List the enzymes involved in the lactate → glucose pathway. (b) What is the net gain/loss of ATP for one round of the Cori cycle (glucose → lactate → glucose)?arrow_forward
- 10) The glycerol phosphate shuttle functions in. A) Lipid catabolism C) Anaerobic glycolysis for the regeneration of NAD 8) Triglyceride synthesis D) Aerobic glycolysis to transport NAH equivalents resulting from glycolysis into mitochondria. 11) In muscles, the pyruvate is converted into lactate. Find the correct statement A) During lactate formation, NADH is reconverted into NAD B) During the product of lactate two AT are produced C) Lactate is the substrate from the downstream pathway D) Lactate acts as the substrate for the formation of amino acid 12) Which of the following regulates lipolysis in adipocytes A) Activation of fatty acid synthesis mediated by CAMP 8) Glycerol phosphorylation to prevent futile esterification of fatty acids C) Activation of triglyceride lipase as a result of hormone stimulated increases in cAMP levels D) Activation of cAMP production by Insulin 13) Glycolysis consists of three irreversible steps. Which of the following enzyme catalyzes the reaction are…arrow_forwardWhat should be the net yield of ATP in glycolysis when endogenous glycogen is used? Give answer as a numeric value.arrow_forwardIndicate whether the following statements are true or false:- a) The pentose phosphate pathway of glucose oxidation can lead to the release of energy. b) NAD + is a coenzyme of transketolase.arrow_forward
- a) Identify three differences between glycolysis and gluconeogenesis. b) Why should we avoid just seeing these processes of reversals of each other?arrow_forwardIn the living cell, free energy made from one reaction can be used to drive another in an energetically unfavorable direction, provided the two reactions have a common intermediate (this is termed the principle of common intermediates). Example: In glycolysis, glucose is converted into pyruvate; in gluconeogenesis, pyruvate is converted into glucose. However, the actual ΔG for the formation of pyruvate from glucose is about -84 kJ/mol under typical cellular conditions. Most of the decrease in free energy in glycolysis takes place in three essentially irreversible steps catalyzed by, hexokinase, pyruvate kinase and phosphofructokinase. Use one of the 3 opposing reactions (in glycolysis and gluconeogenesis) to demonstrate the PRINCIPLE OF COMMON INTERMEDIATESarrow_forwardConsider an alternative glycolysis pathway that starts with the phosphorylation of glucose to give glucose-6-phosphate. This (hypothetical) pathway exists in a (hypothetical) organism that does not express glucose-6-phosphate isomerase. Instead, the next step of this hypothetical pathway is a Glucose-6-Phosphate Aldolase. Draw the product or products that would be obtain by the reaction of Glucose – 6 – Phosphate with Glucose – 6 Phosphate Aldolase. Assume the reaction is completely irreversible. Explain in 1-3 sentences how you obtained your answerarrow_forward
- a) Using full chemical structures of substrates and products, draw the two possible pyruvate reduction pathways that regenerate NAD+ from NADH in the absence of oxygen gas. Give names of all compounds and enzymes involved. b) Draw the step in glycolysis that requires at least one of the above pathways to be functional in the absence of oxygen. Give names of all compounds and enzymes involved.arrow_forwardIn some tissues, glucose 6-phosphate is oxidized to pentose phosphates by the pentose phosphate pathway. a) Which tissues prefer this pathway and why? Explain in detail. b) Due to the fact that glucose 6-phosphate is also an intermediate for the glycolysis pathway, the regulation of glycolysis and pentose phosphate pathway is very important. NADPH plays a crucial role in partitioning of glucose 6-phosphate between glycolysis and the pentose phosphate pathway. Explain this role of NADPH in detail.arrow_forwardFor each of the following molecules determine how much ATP would be net from aerobic cellular respiration. Show your work. Which of the following produces the most energy? (a) Triglycerides are first digested into glycerol and fatty acids. The catabolism of this triglyceride yields: 1 DHAP molecule, 15 FADH2, 15 NADH, and 18 acetyl- COA. (b) Proteins are first digested into individual amino acids. Deamination removes the amine group from each amino acid. The resulting catabolism produces 12 pyruvate molecules.arrow_forward
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