Organic Chemistry
9th Edition
ISBN: 9781305080485
Author: John E. McMurry
Publisher: Cengage Learning
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Textbook Question
Chapter 28.SE, Problem 33AP
What amino acid sequence is coded for by the following DNA coding strand (sense strand)?
(5') CTT-CGA-CCA-GAC-AGC-TTT (3')
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4) Paxlovid is treatment for COVID-19 that was recently approved for use because it can
drastically reduce the risk for hospitalization and death when taken early in the
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to and inhibit the main protease (MPro) from the SARS-CoV-2 virus. This protease
recognizes and hydrolyzes peptide bonds at specific points in their sequence, and it is
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appropriate stereochemistry for biological amino acids and assuming the peptide is at physiological
pH (pH = 7.4).
SGVTFQGKF
b. What would the net charge of the peptide be at physiological pH?.
c. At what pH would the peptide be net neutral?
Which dipeptide(s), (i)-(iv), may be formed in the reaction of
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Glycine Phenylalanine
H2N-
CH2-
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(0
CH-
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OH
(M)
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CHy-C-OH
HN-
CH-C
CH-N-N-
Ph
O ) only
O (ii) only
KO ) and (iv)
O ) and (ii)
iM only
C)
СНО
HO-C-OH
CH,OH
D)
ÇOOH
H-C-OH
CH;OH
39. DNA isolated from human cheek cells was found to contain 20% guanine. What percent of the
nucleotides in this DNA would be cytosine?
A) 20%
В) 30%
C) 40%
D) 80%
40. Which statement below is true regarding peptide hydrolysis?
A) Water is formed.
B) The side chains (R groups) are broken from the carbon.
C) It requires extra amino acids to serve as catalysts.
D) Carboxylic acid and amine groups are formed.
41. The biochemical that is considered insoluble fiber is classified as a
A) carbohydrate.
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Chapter 28 Solutions
Organic Chemistry
Ch. 28.1 - Draw the full structure of the DNA dinucleotide...Ch. 28.1 - Draw the full structure of the RNA dinucleotide...Ch. 28.2 - What sequence of bases on one strand of DNA is...Ch. 28.4 - Show how uracil can form strong hydrogen bonds to...Ch. 28.4 - What RNA base sequence is complementary to the...Ch. 28.4 - From what DNA base sequence was the following RNA...Ch. 28.5 - List codon sequences for the following amino...Ch. 28.5 - List anticodon sequences on the tRNAs carrying the...Ch. 28.5 - What amino acid sequence is coded by the following...Ch. 28.5 - What is the base sequence in the original DNA...
Ch. 28.7 - Prob. 11PCh. 28.7 - Prob. 12PCh. 28.SE - Identify the following bases, and tell whether...Ch. 28.SE - Identify the following nucleotide, and tell how it...Ch. 28.SE - Amine bases in nucleic acids can react with...Ch. 28.SE - The final step in DNA synthesis is deprotection by...Ch. 28.SE - The final step in the metabolic degradation of...Ch. 28.SE - One of the steps in the biosynthesis of a...Ch. 28.SE - One of the steps in the metabolic degradation of...Ch. 28.SE - One of the steps in the biosynthesis of uridine...Ch. 28.SE - Human brain natriuretic peptide (BNP) is a small...Ch. 28.SE - Human and horse insulin both have two polypeptide...Ch. 28.SE - The DNA of sea urchins contains about 32% A. What...Ch. 28.SE - The codon UAA stops protein synthesis. Why does...Ch. 28.SE - Which of the following base sequences would most...Ch. 28.SE - For what amino acids do the following...Ch. 28.SE - Prob. 27APCh. 28.SE - Prob. 28APCh. 28.SE - Draw the complete structure of the ribonucleotide...Ch. 28.SE - Draw the complete structure of the...Ch. 28.SE - Give an mRNA sequence that will code for the...Ch. 28.SE - Give an mRNA sequence that will code for the...Ch. 28.SE - What amino acid sequence is coded for by the...Ch. 28.SE - What amino acid sequence is coded for by the...Ch. 28.SE - Prob. 35APCh. 28.SE - Show the steps involved in a laboratory synthesis...Ch. 28.SE - Draw the structure of cyclic adenosine...Ch. 28.SE - Prob. 38AP
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- 22-82 (Chemical Connections 22H) How does the fiberscope help to heal bleeding ulcers?arrow_forward22-28 A tetrapeptide is abbreviated as DPKH. Which amino acid is at the N-terminus, and which is at the C-terminus?arrow_forwardThe -chain of hemoglobin is a protein that contains 146 amino acids residues. What minimum number of nucleotides must be present in a strand of mRNA that is coded for this protein?arrow_forward
- What sequence of bases on one strand of DNA is complementary to the following sequence on another strand? (5') GGCTAATCCGT (3')arrow_forwardIs the trinucleotide in Problem 22-32 found only in DNA, found only in RNA, or found in both DNA and RNA? Explain the basis for your answer.arrow_forward22-33 Which of the three functional groups on histidine is the most unique?arrow_forward
- Human and horse insulin both have two polypeptide chains, with one chain containing 21 amino acids and the other containing 30 amino acids. They differ in primary structure at two places. At position 9 in one chain, human insulin has Ser and horse insulin has Gly; at position 30 in the other chain, human insulin has Thr and horse insulin has Ala. How must the DNA for the two insulins differ?arrow_forwardThe DNA of sea urchins contains about 32% A. What percentages of the other three bases would you expect in sea urchin DNA? Explain.arrow_forward22-47 How many different tetrapeptides can be made (a) if the peptides contain the residues of asparagine, proline, serine, and metbionine and (b) if all 20 amino acids can be used?arrow_forward
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