a) I-L-P-F
Interpretation:
The structure of the PTH derivative product that is obtained by Edman degradation of the peptide I-L-P-F is to be given.
Concept introduction:
Edmund degradation involves treatment of a peptide with phenyl isothiocyanate, followed by reaction with trifluoroacetic acid when an anilinothiazolinone (ATZ) is produced. This ATZ rearranges in the presence of acids to yield N-phenylthiohydantoin.
To give:
The structure of the PTH derivative product that is obtained by Edman degradation of the peptide I-L-P-F.
b) D-T-S-G-A
Interpretation:
The structure of the PTH derivative product that is obtained by Edman degradation of the peptide D-T-S-G-A is to be given.
Concept introduction:
Edmund degradation involves treatment of a peptide with phenyl isothiocyanate, followed by reaction with trifluoroacetic acid when an anilinothiazolinone (ATZ) is produced. This ATZ rearranges in the presence of acids to yield N-phenylthiohydantoin.
To give:
The structure of the PTH derivative product that is obtained by Edman degradation of the peptide D-T-S-G-A.
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Chapter 26 Solutions
Organic Chemistry
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