The synthesis method of labetalol from salicylic acid and benzyl chloride has to be proposed. Concept Introduction: Retrosynthetic analysis: In an organic synthesis , the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

Question

Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of the neurotransmitter serotonin in the synapses of the central nervous system follow- ing release of serotonin during excitation of individual nerve cells. Between firings, the serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of reuptake has the effect of increasing the time serotonin molecules remain in the syn- apses following excitation, leading to a therapeutic effect. In one synthesis of parox- etine, the following reagents are used. Draw the structures of synthetic intermediates A and B. F НО SOCI, A B HO Pyridine

Answer 1

Question

Chapter 22, Problem 22.57P

(a)

Interpretation Introduction

Interpretation:

The synthesis method of labetalol from salicylic acid and benzyl chloride has to be proposed.

Concept Introduction:

Retrosynthetic analysis:

In an organic synthesis, the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

(b)

Interpretation Introduction

Interpretation:

The structure of dilevalol with its configuration has to be given.

Concept Introduction:

Stereoisomers and chiral:

Isomers differing only in their spatial arrangement of atoms are called as stereoisomers.

The geometric property of a molecule that cannot be superimposed on its mirror image is known as chirality. Chiral carbon is the one which is attached with four different groups or atoms.

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