Organic Chemistry (9th Edition)
Organic Chemistry (9th Edition)
9th Edition
ISBN: 9780321971371
Author: Leroy G. Wade, Jan W. Simek
Publisher: PEARSON
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Chapter 20.14, Problem 20.21P

(a)

Interpretation Introduction

Interpretation:

The synthesis of given ketone from the indicated acid is to be shown.

Concept introduction:

The synthesis of compound relies upon the type of reactants and reagents that are used during the reactions.

The energy of the product should be low because low energy of a compound increases the stability of a compound. The stability of a compound is the major factor that is responsible for the formation of a compound. The reagents perform numerous functions in reactions like proton abstraction, oxidation, reduction, catalysis, and dehydrogenation.

(b)

Interpretation Introduction

Interpretation:

The synthesis of given ketone from the indicated acid is to be shown.

Concept introduction:

The synthesis of compound relies upon the type of reactants and reagents that are used during the reactions.

The energy of the product should be low because low energy of a compound increases the stability of a compound. The stability of a compound is the major factor that is responsible for the formation of a compound. The reagents perform numerous functions in reactions like proton abstraction, oxidation, reduction, catalysis, and dehydrogenation.

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Why is it not advisable to use aqueous hydrochloric acid in a Grignard reaction of a ketone? A) The Grignard reagent will react with the acid and cannot react with the ketone. B) The ketone will be protonated and will become unreactive. C) The ketone will form an unreactive enol. D) The Grignard reagent won't dissolve in aqueous solutions
Provide an explanation (in detail) on how base catalysts speed up nucleophilic reactions of carbonyl compounds.
What is the major difference between the base-catalyzed and acid-catalyzed processes for nucleophilic addition of water to aldehydes and ketones? a. The base-catalyzed reaction takes place rapidly because hydroxide ion is a much better nucleophile than neutral water. b. The rate of reaction in base catalyzed process is slower than acid catalyzed process. c. The acid-catalyzed reaction takes place rapidly because the protonated carbonyl compound is a much better electrophile than the neutral compound. d. Only 1 and 3 are correct.

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Organic Chemistry (9th Edition)

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