Concept explainers
To review:
The factors which are considered as ”reactive” activators and inhibitors in the active zone, during the pattern formation in organogenesis.
Introduction:
Turing's model is described as one of the very important models in developmental biology, which is formulated by the Alan Turing (1952), one among the founders of computer science. The reaction-diffusion mechanism is a mathematical model which predicts alternating areas of high and low concentrations of some substance. He also explains the generation of complex patterns from the substances which are initially distributed homogeneously. The reaction part of this model is unique for this mechanism. This model explains that molecular prepatterns are dependent on reactant's interactions which spontaneously generate a non uniform pattern.
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Developmental Biology
- Practice question 1B) Mutations in the signalling pathways depicted above have been associated with an increased incidence of several types of cancer. Individuals with the se cancers may be treated with one of the following chemotherapeutic drugs. Complete the table below about their me chanisms of action. In which cellular Which process is targeted first compartment/structure/organelle by this drug? Drug Drug's mechanism of action does this proce ss occur? (replica tion, mitosis, transcription, translation, or If more than 1 location, be sure to specify ALL relevant locations. none of the above)? A Inhibits microtubule assembly Create inter- or intra-strand crosslinking in DNA preventing strand separation Inhibits synthesis of non-essential amino acids Drug CH3 HN HN PPPO O N. PPPO O OH OH 5-deoxythymydine triphosphate (DTTP) 5-deoxyuridine triphosphate (DUTP)arrow_forwardPractice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits the TSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst PI3K PTEN Lats AKT 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. (miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in…arrow_forwardPractice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. MTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits theTSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN T Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. (miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in…arrow_forward
- Practice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. MTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits theTSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. miR-29 YAP TSC2-TSC1 amino acids Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb Rag-Ragulator cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in…arrow_forwardPractice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway - 3. The activated Akt, a serine threonine kinase, inhibits theTSC1–TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- ator con miR-29 YAP TSC2-TSC1 lex. amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn…arrow_forwardQuestion:- Protein kinase inhibitors have become a major focus for the development of molecularly targeted cancer therapies. Based on what you know from the development of Gleevec, what are at least two generalizable principles that apply to the development of all tyrosine kinase inhibitors? What is a potential pitfall of targeting a protein kinase for cancer treatment? (Relate back to Gleevec example - this answer should include three separate concepts – 2 principles, 1 limitation)arrow_forward
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