The construction of a linkage map to determine the order of six linked genes, which include a, b, c, d, e, and f, to determine the map units between them. Introduction: A linkage map (also called the genetic map) is a chromosomal map that indicates the genes of species and variously related markers. The recombination frequency is necessary to construct a linkage map. In the condition when two or more genes are linked together, the chances of crossover increases, producing recombination. A linkage map is used to determine the position of two genes on the same chromosome. It is not used to identify the physical distance between the genes.

Question

Proteins A,B,C, and D in the diagram are encoded by different genes and interact with each other. Imagine that a mutation in the gene for protein A changes one of the charged amino acid in the red circle area from positive to negative charge (blue arrow). this mutation results in a mutant phenotype. Assume a mutation in the gene for protein B occurs and the double mutants have a phenotype that is almost wild type. How would you best describe the mutation in gene B? Protein C Proten A Protein B Protein B Wild type Mutation in the gene for protein A

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Question

Chapter 13, Problem 13TYK

Summary Introduction

To review:

The construction of a linkage map to determine the order of six linked genes, which include a, b, c, d, e, and f, to determine the map units between them.

Introduction:

A linkage map (also called the genetic map) is a chromosomal map that indicates the genes of species and variously related markers. The recombination frequency is necessary to construct a linkage map. In the condition when two or more genes are linked together, the chances of crossover increases, producing recombination. A linkage map is used to determine the position of two genes on the same chromosome. It is not used to identify the physical distance between the genes.

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Proteins A,B,C, and D in the diagram are encoded by different genes and interact with each other. Imagine that a mutation in the gene for protein A changes one of the charged amino acid in the red circle area from positive to negative charge (blue arrow). this mutation results in a mutant phenotype. Assume a mutation in the gene for protein B occurs and the double mutants have a phenotype that is almost wild type. How would you best describe the mutation in gene B? Protein C Proten A Protein B Protein B Wild type Mutation in the gene for protein A

In this gene order question, would the order be a/b -- kf -- nm since genes with shorter map unit distances are closely linked?

In the fungus Neurospora, a strain that is auxotrophic for thiamine (mutant allele t) was crossed with a strain that isauxotrophic for methionine (mutant allele m). Linear asci were isolated and classified into the following groups: a. Determine the linkage relations of these two genes to their centromere(s) and to each other. Specify distances in map units. b. Draw a diagram to show the origin of the ascus type with only one single representative (second from right).