Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 12, Problem 13QP
The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the media (for example, Newsweek, December 6, 1993). Describe the steps taken by Mary-Claire King and her colleagues to clone this gene. How long did this process take?
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Sarah has always lived what many consider an active and healthy lifestyle. She makes a conscious
effort to eat well and exercise daily, never smoked, and drinks moderately. Many of Sarah's female
relatives (including her mother and grandmother) have had breast cancer. Sarah has decided to have
her genome sequenced. She is specifically interested in whether she shows mutations in BRCA1 and
BRCA2 that are linked to breast cancer. What information can be drawn from the sequence data
Sarah will receive? Justify your answer.
• Sarah will know if she will develop breast cancer.
• Sarah will know if and when she will develop breast cancer.
• Sarah will know the severity of her breast cancer based on the number of mutations; that is, the
more mutations in those genes, the greater the severity of the disease.
• Sarah will know whether she is predisposed to breast cancer.
• Sarah will know that she will not develop breast cancer if there are no mutations in those genes.
Cap, EA1, and Sap are all genes/proteins of interest in this study. For each gene, what gene product is encoded and where is the gene (the literal DNA sequence) located physically in the cell?
I need help fimiding this in the artticle and answer as short as possible
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC106848/
Another cancer cell line that you are working on came from a patient in your medical clinic. You
recognize that this is a new type of breast cancer that has never been described before.
a. How could you use sequence analysis to determine if this patient inherited the mutation
from one of her parents or if it spontaneously occurred in her cells? (Unfortunately her
parents have passed away.)
b. How could you use sequence analysis to determine if this gene is a tumor suppressor or
an oncogene? (For partial credit briefly define tumor suppressor and oncogene.)
Chapter 12 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 12.10 - If improved diagnostic tests are developed from...Ch. 12.10 - If you had cancer, would you donate tissue samples...Ch. 12.10 - Prob. 1GRCh. 12.10 - Another model, the random model, proposes that any...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Theodor Boveri predicted that malignancies would...Ch. 12 - Distinguish between a familial and a sporadic...Ch. 12 - Benign tumors: a. are noncancerous growths that do...
Ch. 12 - Prob. 4QPCh. 12 - Prob. 5QPCh. 12 - Prob. 6QPCh. 12 - Prob. 7QPCh. 12 - Prob. 8QPCh. 12 - What is the difference between a proto-oncogene...Ch. 12 - Distinguish between dominant inheritance and...Ch. 12 - Describe the likelihood of developing bilateral...Ch. 12 - Prob. 12QPCh. 12 - The search for the BRCA1 breast cancer gene...Ch. 12 - What are the roles of cellular proto-oncogenes,...Ch. 12 - Which of the following mutations will result in...Ch. 12 - Prob. 16QPCh. 12 - The following family has a history of inherited...Ch. 12 - You are in charge of a new gene therapy clinic....Ch. 12 - Prob. 19QPCh. 12 - Can you postulate a reason or reasons why children...Ch. 12 - Prob. 21QPCh. 12 - In Section 12-1, Julie is concerned that she may...Ch. 12 - Prob. 23QPCh. 12 - What are some factors that epidemiologists have...Ch. 12 - Smoking cigarettes has been shown to be associated...Ch. 12 - Prob. 26QPCh. 12 - Studies have shown that there are significant...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A couple with a child affected with DBA undergoes in vitro fertilization (IVF) and genetic testing of the resulting embryos to ensure that the embryos will not have DBA. However, they also want the embryos screened to ensure that the one implanted can serve as a suitable donor for their existing child. Their plan is to have stem cells from the umbilical cord of the new baby transplanted to their existing child with DBA, thereby curing the condition. What are the ethical pros and cons of this situation?arrow_forwardA graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max). Oncogene? GADPH Normal Tumor 1 Tumor 2 Tumor 3arrow_forwardA graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max).arrow_forward
- Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her MD/PhD in cancer therapeutics to treat late-stage pancreatic cancer using a mouse model. Her post-doc will be devoted to targeted mutagenesis of replicative enzymes to halt cell division in cancerous cells. She reviews mitosis and meiosis before reporting for her first day of work. 1) If Dr. Velazquez was asked to review an article on the possibility of targeted mutagenesis of the gene for DNA pol III in a human fetus to make it immune to cancer, what do you think her response would be? a) LMAO! No human would survive without pol III since we need it to help resolve the issue with Okazaki fragments! b) LOL! Humans aren’t bacteria so WT* are the researchers even thinking?! c) LMAO! DNA pol I is the main replicative DNA polymerase. d) Hmmm! Why didn’t I think of that?!!arrow_forwardDo a few cells created by therapeutic cloning of your own somatic cells constitute life? If these cells do constitute life, do they have the same rights as a human being conceived naturally? If it were possible, should someone be allowed to grow his or her own therapeutic clone into an adult?arrow_forwardTransgenic organisms are only possible because widely different organisms share a common mechanism for DNA replication, transcription, and translation. What are the implications of this on their evolutionary origin?arrow_forward
- Dolly is the first mammal to have been successfully cloned from an adult cell Which of the following statement/s is/are most relevant to the birth of Dolly? I. It suggests that human could be cloned. II. It proves that specialized cells could be used to create an exact copy of the animal they came from. III. It improves the production of milk, meat, and other products from livestock. IV. It proves that animals could be cloned to have gene mutations that help scientists study diseases that develop in the animals. A. II only B. I and II C. III, and IV D. II, III, and IV Which of the following statements best explain the significance of mitosis and ? A. Both mitosis and meiosis produce diploid cells which responsible for the continuity of life. B. Many single-celled organisms rely on mitosis and meiosis as their primary means of asexual reproduction C. replication, cells have another interesting choice, whether they want to make an identical copy, or do they want to make four half-copies…arrow_forwardIn contrast with the genomic manipulations of animals and plants described in this chapter, human genetherapy is directed specifically at altering the genomes of somatic cells rather than germ-line cells.Why couldn’t or wouldn’t medical scientists try to alter the genome of human germ-line cells?arrow_forwardWooly Mammoths have been extinct for about 10,000 years; however, their remains have been well persevered in Siberia. Due to global warming, these remains are now available to be recovered. Scientists want to extract the DNA and through cloning insert the DNA into an elephant to clone the mammoth. What are some of the pros and cons of cloning an extinct animal?arrow_forward
- A controversial issue, closely related to cloning, that has caused a lot of debate is the use of embryonic stem cells. One possible application of these cells is that they may be able to supply replacement tissues to treat diseases such as Parkinson's disease, diabetes, paralysis due to spinal cord injuries, and other degenerative diseases. The word "embryonic", has caused fierce opposition to this type of research because embryos are destroyed when the stem cells are removed. Questions that have surfaced in this debate include: When a cell nucleus is transferred to another cell, have we created life? Does a stem cell have the same status as a human? What should be done with the embryos that are leftover at in vitro fertilization (IVF), clinics? Advocates argue that the medical benefits of stem cell research would be enormous. Opponents argue that life begins at conception and thus this type of research is abortion. Based on what you have read, explain why you are for or against stem…arrow_forwardAnswer each of the following questions correctly.(2-5 sentences only)(DO NOT USE THE EXAMPLE I PROVIDED FOR YOUR ANSWER( A. How cloning and expression of certain genes allows for massive production of the desired product.(Give an specific example, AGAIN PLEASE DO NOT USE THIS EXAMPLE AS YOUR EXAMPLE FOR MY QUESTION. YOU ARE NOT ALLOWED TO COPY AND PASTE MY EXAMPLE FOR YOUR ANSWER. PLEASE PROVIDE ANOTHER EXAMPLE .DO NOT USE MY EXAMPLE) For example: the cloning and expression of insulin in bacteria allows for the mass production of this necessary protein for use by diabetic patients.arrow_forwardThe story of Dolly the sheep remains as a major breakthrough in the field of science as the first mammal to have been cloned from adult cell. Dolly was born on July 5, 1996 at the Roslin Institute in Scotland and live up to six years when she was put to sleep on February 14, 2013 by euthanasia (retrieved from https://dolly.roslin.ed.ac.uk on August 25, 2021). If the intention of the project is for a noble purpose, will you consider this kind of cloning ethical for the sake of science and the benefit of mankind or would you think it goes against your faith and religious beliefs?arrow_forward
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