All the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (E'º for NAD+/NADH is −0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently-bound FAD (E'° for FAD/FADH₂ in this enzyme is 0.050 V). The E' value for fumarate/succinate is 0.031 V. Calculate the AG'° value for the oxidation of succinate using NAD+. AG'° = Calculate the AG'° value for the oxidation of succinate using covalently-bound FAD. AG'° = +67.55 -3.667 The kJ/mol kJ/mol Based on the E'° values of fumarate/succinate, NAD+/NADH, and the succinate dehydrogenase FAD/FADH2, why is FAD a more appropriate electron acceptor than NAD+ in the dehydrogenation of succinate? positive standard free-energy change favors the oxidation of succinate by covalently-bound FAD. This is consistent with K'eq = 1. Oxidation by NAD+ would require a large, negative standard free-energy change, with K'eq favoring the synthesis of succinate.
All the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (E'º for NAD+/NADH is −0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently-bound FAD (E'° for FAD/FADH₂ in this enzyme is 0.050 V). The E' value for fumarate/succinate is 0.031 V. Calculate the AG'° value for the oxidation of succinate using NAD+. AG'° = Calculate the AG'° value for the oxidation of succinate using covalently-bound FAD. AG'° = +67.55 -3.667 The kJ/mol kJ/mol Based on the E'° values of fumarate/succinate, NAD+/NADH, and the succinate dehydrogenase FAD/FADH2, why is FAD a more appropriate electron acceptor than NAD+ in the dehydrogenation of succinate? positive standard free-energy change favors the oxidation of succinate by covalently-bound FAD. This is consistent with K'eq = 1. Oxidation by NAD+ would require a large, negative standard free-energy change, with K'eq favoring the synthesis of succinate.
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter20: Electron Transport And Oxidative Phosphorylation
Section: Chapter Questions
Problem 7P
Related questions
Question
Check this problem and explain your answer. Especially the fill in the black part at the bottom of page.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning