Given the DDF (Density Displacement factor) for morphine HCI is 1.6, calculate the quantity of cocoa butter needed to prepare the following: Morphine HCI: 100mg Cocoa butter: Q.S Quantity of suppositories to make: #7
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- Table 1: Arterial blood gas concentration in patient Two hours after aspirin ingestion Ten hours after aspirin ingestion Normal values Partial Pressure CO2 26 mm Hg 19 mm Hg 35-45 mm Hg Partial Pressure O2 113 mm Hg 143 mm Hg 75-100 mm Hg Bicarbonate [HCO;] 18 mM 21 mM 22-26 mM pH 7.44 7.55 7.35-7.45 Blood salicylate concentration, mg/dL 57 1171000 mg of Drug Q (F=1, S=1) is given by i.v. bolus. Drug Q has two-compartment PK (IBD2) and it is found from data that A=73 mg/L, B=18 mg/L, alpha=1.02 hr-1, beta=0.375 hr-1. Please find Vdβ, round to the nearest tenthAspirin is considered as an acidic drug given at a dose of 80 mg tablet as an antithrombotic agent for patients with angina and prevention of myocardial and cerebral infarction. In today’s market, some preparations of aspirin would be given as 100 mg enteric coated tablet. Why is the enteric coated tablet given in 100 mg dose as compared to the compressed tab of 80 mg only?
- A prescription order calls for 1.25 g of vancomycin in 500 mL of NS (0.9%/100mL). After reconstitution vancomycin injection is available in a strength of 50 mg/mL. How many mL of vancomycin injection should be drawn up to prepare this prescription?Mrs B presents you with a prescription for warfarin tablets 1 mg. The directions are to take 6 mg at 6pm that evening, followed by alternating daily doses of 4 mg and then 3 mg (as long as her INR remains within the recommended range). What is the exact number of warfarin 1 mg tablets required for a 28 day supply assuming her INR remains in range?A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.
- The drug dosage for the patient is calculated using a BSA of 1.9m2. If the order is 15mg per m2, how many milligrams is the desired dose?The following is HPLC data. Using the standard curve determine the concentration of caffeine in each sample in µg/µl: Sample Peak area Volume of sample Amount of caffeine µg/ µl 1 1305490 1 µl 2 7836463.3 1 µl 3 3476413.7 1 µl 4 2936950.7 1 µl 5 15452894 1 µl 6 958353.7 1 µl 7 592743.3 1 µl 8 557099 1 µl 9 653410.7 1 µl 10 734443.7 1 µlDigitalis, a drug used to control atrial fibrillation in patients is to be delivered to have a the drug amount to 20.0 μμg/kg body weight (2.205 pounds = 1.00 kg). The drug concentration must be carefully controlled and accurately measured or the patient may die from too low of concentration from heart complications or too high concentrations of fatal overdose. Calculate the mL of digitalis needed to treat a 160.0 pound patient using 0.800 mg/mL digitalis solution.
- Using the normal arterial blood gas values (pH = 7.35-7.45; Paco2 = 35-45 mm Hg; HCO3- = 22-26 mEq/L), identify both the primary disturbance and the degree of compensation for these three arterial blood gas readings: (a) pH = 7.20 (b) pH = 7.20 (c) pH = 7.36 Paco2 = 35 mm Hg Paco2 = 25 mm Hg Paco2 = 20 mm Hg [HCO3-] = 17 mEq/L [HCO3-] = 17 mEq/L [HCO3-] = 17 mEq/LA child weighing 22 lbs, has an infection and the doctor orders erythromycin drops 2.0 mLp.o. q6h. The bottle states that the usual dosage is 20.0-40.0 mg/kg/day, and there are35.0 mg per 1.5 mL. Find the min and max dosage per day in mL. Is the order within therecommended dosage?The hospital pharmacy receives an order for morphine sulfate 1/4g IM stat. The concentration on hand is 10mg per mL. How many mL is needed for the dose?