Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 22.3, Problem 1CC

Explain how the following Statement is inaccurate: "Antibiotics have created drug resistance in MRSA."

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Penicillin was first used in the 1940s to treat gonorrhea infections produced by the bacterium Neisseria gonorrhoeae. In 1984, according to the CDC, fewer than 1% of gonorrhea infections were caused by penicillin-resistant N. gonorrhoeae. By 1990, more than 10% of cases were penicillin resistant and a few years later the level of resistance was 95%. Explain the various ways this resistance could be spread among the cells. Could this resistance pass to other infectious bacteria from N. gonorrhoeae?
In 1971, Alfred Knudson noticed that children like Kay, who have retinoblastoma in both eyes (bilateral), presented at earlier ages than those who had unilateral disease. To explain these different disease kinetics, he proposed the “two-hit hypothesis.” What does this hypothesis propose?
The epidemiological or disease triangle is a model of disease causation that proposes three factors contribute to an outbreak - an agent that causes the disease, a susceptible host, and an environment that brings the host and agent together. Some general changes within these three factors that may cause an infectious disease to emerge include: A. changes in populations or behavior of reservoir hosts or intermediate hosts B. microbial genetic mutation and viral genetic recombination or assortment C. environmental factors such as an increase in precipitation D. all of the above E. none of the above
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