Why is a strong acid (like HCI) used in a Grignard reaction? A strong acid is used in the Grignar reaction in order to protonate the 1) carbonyl in order to make a better leaving group, OH. Once teh OH leaves, the alcohol group is reformed due to water. A stable tetrahedral intermediate with a negatively charged oxygen forms 2) that does not possess a leaving group. This intermediate will exist until a proton source from the strong acid protonates the negatively charged oxygen, affording the neutral alcohol product. 3) The use of a strong acid is not necessary. It is simply recommended as it increases the yield produced in the reaction. The use of a strong acid is necessary for the formation of a Grignard 4) reagent. Without a strong acid, the organomagnesium compound cannot be formed.

Why is a strong acid (like HCI) used in a Grignard reaction? A strong acid is used in the Grignar reaction in order to protonate the 1) carbonyl in order to make a better leaving group, OH. Once teh OH leaves, the alcohol group is reformed due to water. A stable tetrahedral intermediate with a negatively charged oxygen forms 2) that does not possess a leaving group. This intermediate will exist until a proton source from the strong acid protonates the negatively charged oxygen, affording the neutral alcohol product. 3) The use of a strong acid is not necessary. It is simply recommended as it increases the yield produced in the reaction. The use of a strong acid is necessary for the formation of a Grignard 4) reagent. Without a strong acid, the organomagnesium compound cannot be formed.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter24: Catalytic Carbon-carbon Bond Formation

Section: Chapter Questions

Problem 24.9P

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