Which of the following disorders in humans has an X-linked recessive inheritance pattern? a.Hutchinson-Gilford progeria b.Tay-Sachs disease c.Marfan syndrome d.Red-green color blindness
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- Fragile X is a disorder which causes mental impairment in affected individuals. The trait which is due to a mutation in the FMR1 gene on the X chromosome is inherited in a recessive manner. An unaffected son was born to an affected man and an unaffected woman. The woman’s mother was affected while the father was normal. a. Indicate the gene notation. b. Give the genotype of the son. c. Is it possible for the couple to have an affected daughter? affected son? Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly. d. If the couple has four children, what is the probability that they will have three normal daughters and one normal son?A male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: Oa. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% LENA C Transcribed Image Text: A male has a particular X-linked recessive genetic disorder. His partner is normal, but her father had the disorder. What is the chance that their sons will have the disorder? Select one: O a. 50% O b. 0% O c. 100% O d. impossible to determine from the information given. O e. 25% Po 11 W *****Which of the following is indicated by roman numerals in a pedigree? a.Presence of the studied trait b.Generation c.Sex d.Marriage status Which of the following disorders in humans has an autosomal dominant inheritance pattern? a.Albinism b.Hemophilia c.Tay-Sachs disease d.Huntington’s disease For an X-linked recessive allele, what proportion of female offspring will be carriers in the cross of an affected father and a noncarrying mother? a.50 percent b.0 percent c.100 percent
- A patient has mental deficiency, a short stature, and the mongolian type of the eyelid fold. The microscopical examination of the patient's karyotype revealed the presence of trisomy on the 21-st chromosome. What do we call the disease which is caused by this chromosomal abnormality? Select one: a. Down's syndrome. b. Klinefelter's syndrome. O c. Turner's syndrome. d. Edward's syndrome. e. Patau syndrome.For items 1-10, refer to the choices below: a. Williams Syndrome b. Cri-Du-Chat Syndrome c. Pallister-Killian Syndrome d. Wolf-Hirschhorn Syndrome 1. Caused by a deletion in chromosome 5. 2. Has bulging, wide-set eyes. 3. Has hypertelorism. 4. Caused by an isochromosome. 5. Caused by the deletion of multiple genes on chromosome 7. 6. About 30% of the people with this disorder are autistic. 7. They have an elf-like face. 8. Has a high chance of having scoliosis. 9. White starburst pattern around the irisDuring the pathoanatomic inspection of a baby-boy's dead body the following abnormalities: polydactily, microcephaly, a cleft lip and cleft palate, hypertrophy of the parenchymal organs were found. These symptoms are typical of Patau syndrome. What is the cause of this disease? Select one: a. Trisomy on the 21st chromosome. O b. Trisomy on the 18th chromosome. c. Trisomy on the 13th chromosome. d. Trisomy on X chromosome. e. Monosomy on X chromosome.
- What was the hypothesis of the X-linked cross conducted in the lab (between white-eyed female and re-eyed male) with the white mutation in Drosophila and written up in your lab report? A All female offspring will inherit red eyes from their mother because the mutation is X linked recessi B All female offspring will inherit white eyes from their mother because the mutation is X linked recessive. C All male offspring will inherit white eyes from their mother because the mutation is X linked recessive. D All male offspring will inherit red eyes from their mother because the mutation is X linked recessive. E All male offspring will inherit white eyes from their mother because the mutation is X linked dominant.In which of the following does one gene control the expression of another, independently inherited gene? a. Pleiotropy b. Epistasis c. Multifactorial inheritance d. codominance e. incomplete penetranceWhich of the following cannot be true about the inheritance the trait depicted in the pedigree diagram below? A. It is recessive B. It is dominant C. It is on the X chromosome D. There is not enough information to determine the mechanism of inheritance
- In humans, color vision depends on genes encoding three pigments. The R (red pigment) and G (green pigment) genes are close together on the X chromosome, whereas the B (blue pigment) gene is autosomal. A recessive mutation in any one of these genes can cause color blindness. Suppose that a color-blind man married a woman with normal color vision. The four sons from this marriage were color-blind, and the five daughters were normal. Specify the most likely genotypes of both parents and their children, explaining your reasoning. (A pedigree drawing will probably be helpful.) (Problem 50 is by Rosemary Redfield.)Solve the following genetic problems involving X-linked inheritance. You must pick the right letter to represent the gene in the question. You must show your work using the Punnett square. 1 In humans, red-green colorblindness is a sex-linked recessive condition. Show a cross between a colorblind man and a woman with normal vision (homozygous normal). What are the possible phenotypes of the children? 18. Suppose a female child from the previous question grows up to marry a man with normal color vision. What are the possible genotypes and phenotypes of their children? 19. Hemophilia is a sex-linked trait where X" gives normal blood clotting and is dominant to the hemophilia allele Xh. a. Give the genotypes of 1) a woman with normal blood clotting whose father had hemophilia and 2) a normal man whose father had hemophilia.Color blindness in humans is controlled by an X-linked completely recessive allele (Xc), while breast cancer is controlled by an autosomal completely dominant allele, B. A color blind male, who is a heterozygote carrier for breast cancer has three children/n with a normal eyed female (whose mother was color blind), who is homozygote recessive for the breast cancer allele. What is the probability that out of three children, 2 will be color blind males, and not show breast cancer, and one will be a color blind female, who shows breast cancer?