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- What is Thalassemia and Hemolytic disorder? Differentiate.
- Name TWO (2) methods that are applicable for serum preservation?
- Explain TWO importance of studying Blood transfusion?
- Give FOUR (4) therapeutic uses of serum?
- conclusion
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- Explain the difference between serum and plasma. Additionally, why is serum the specimen of choice in usual blood analyses?Hancock, a 65-year-old white male, was seen in triage with complaints of fatigue, malaise, anorexia, and hemoptysis of recent onset. A complete blood count (CBC) was ordered and revealed anemia and a shift to the left in granulocytes. Hematopoietic cells showed dysplastic features. Consider diagnostic probabilities and reflex testing that could provide differential diagnostic information. The results of the CBC on Hancock were: The neutrophilic cells show marked hyposegmentation and hypogranulation. Red blood cell (RBC) morphology includes anisocytosis and poikilocytosis, teardrop cells, ovalocytes, and schistocytes. 1- What features of the differential resemble chronic myeloid leukemia (CML)? What helps to distinguish this case from CML? 2- Which of the hematopoietic cell lines exhibit dyshematopoiesis in the bone marrow? 3- How would you classify the bone marrow cellularity? Why? 4- Identify at least two features of the bone marrow that are compatible with the diagnosis 5- What…sickle cell disease and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin . propose a proper therapeutic strategy to ameliorate or cure this disease.
- What is the importance of hemostasis in detail (blood clotting)? Explain the detail steps involved in this process.Differentiate serum from plasma and state how they are collected and prepared prior analysis. Explain in long explanation.WHAT IS THE PRINCIPLE BEHIND BLOOD TRANSFUSION? GIVE EXAMPLE. EXPLAIN COMPREHENSIVELY.
- List several methods (other than bleeding time: Ivy method, clotting time, Lee & White method) and explain the principle of tests for clotting and bleeding time.refer to question: What specimen was compromised from Jake's tests?Why was it compromised?How could have they avoided the problem of drawing blood twice?How do you administer a direct IV or IV bolus? Is direct IV and IV bolus the same? And when you administer via direct IV, does the solution of the direct IV (i.e. ceftazidime, meropenem, etc.) affects the continuous infusion (i.e. Lactated ringer, KCl, NaCl)
- Please describe the difference between blood plasma and blood serum. Please include references.Yasuo Yamagata, a 63-year-old, experienced severe back pain for several weeks before visiting his family physician. He also complained of fatigue and looked pale. Blood analysis revealed a red blood cell count of 3.2 × 106/μl (normal 4.2–5.0 × 106/μl), a white blood cell count of 2800/μl (normal 5000/μl), a sedimentation rate of 30 mm/h (normal <20 mm/h) and a serum IgG of 4500 mg/dl (normal 600–1500 mg/dl). IgA and IgM levels were well below normal. Skeletal survey showed lytic lesions in vertebrae, ribs and skull. A bone marrow sample revealed 75% infiltration with plasma cells. Elevated protein in urine was confirmed to be Bence-Jones protein (immunoglobulin light chains). The patient was diagnosed with IgG λ multiple myeloma and began an immediate chemotherapy regime. Which of the following would be consistent with this type of malignant tumor of plasma cells? a. Serum IgG is polyclonal. b. Anemia and neutropenia are present as the result of plasma-cell infiltration in the…Enumerate and explain briefly the important phenomena in the three stages of primary hemostasis. In the presence of anticoagulants, bleeding time is prolonged. Why Name the important factors necessary for normal bleeding time.