There are a number of pharmacokinetic strategies available to change the absorption of a lead compound during the drug design process. (a) Based on the lead compound shown, draw an analogue which has decreased polarity using two different strategies. The drawing can be done neatly by hand or by using ChemDraw. (b) Clearly label your analogue with the strategy being used for each change. (c) State whether your analogue will be more hydrophillic or hydrophobic than the original lead compound shown. (d) Attach a clear photo of your handwritten structure and answers using an image file or upload a PDF, Powerpoint or Word file containing your ChemDraw structure and answers. Cl CH3
There are a number of pharmacokinetic strategies available to change the absorption of a lead compound during the drug design process. (a) Based on the lead compound shown, draw an analogue which has decreased polarity using two different strategies. The drawing can be done neatly by hand or by using ChemDraw. (b) Clearly label your analogue with the strategy being used for each change. (c) State whether your analogue will be more hydrophillic or hydrophobic than the original lead compound shown. (d) Attach a clear photo of your handwritten structure and answers using an image file or upload a PDF, Powerpoint or Word file containing your ChemDraw structure and answers. Cl CH3
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section18.8: Interconversion Of Functional Derivatives
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