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The Replication of DNA 283 (Concinued). Chapter 9: P molecule ding. es DNA polymerase monitor the incoming base to ensure proper base pairing? How does it prevent RNA from being incorporated? what are some of the ways antiviral and anticancer agents can affect DNA synthesis? How y How often are bases mis-incorporated by DNA polymerase? How does DNA polymerase's prootreading domain detect and remove mis-incorporated bases? What does this improve the error rate to? 19. Describe helicase's structure and function, and the role ATP has on its tertiary structure. 29. Define the function of the following at the replication fork: a. Sliding clamp: b. Sliding clamp loader: Sliding clamp loader's t protein (both functions): C. Compare/contrast the traditional vs. newer hypotheses on DNA replication. 22.1f E. coli incorporated the wrong base during replication, how would it differentiate the original from the new strand for repair? 23. How does Cdk regulate DNA replication? 24. Why do the telomeres shorten with each replication? Which cell types have telomerase to lengthen them? 25. How does telomere length relate to aging and disease? What is the Hayflick Limit and how does it relate to telomeres and aging? 26. What are the advantages of sexual reproduction over asexual reproduction? Chapter 10: 27. Explain DNA mutation with regards to its impact, both positive and negative, on humans. Discuss mutations in intergenic DNA vs. exons, and the potential impact of each. 28. Why do RNA viruses have a higher mutation rate than humans? How might this benefit them? 2 Regarding human mutation rates: How can mitochondrial DNA be used to track lineages? b. Does any paternal mitochondria get passed on to children? c. How can the Y chromosome be used to track lineages? d. When did the common ancestor of everyone alive today live? a. How do mutations and SNPS differ? What is the impact of each on an organism?

The Replication of DNA 283 (Concinued). Chapter 9: P molecule ding. es DNA polymerase monitor the incoming base to ensure proper base pairing? How does it prevent RNA from being incorporated? what are some of the ways antiviral and anticancer agents can affect DNA synthesis? How y How often are bases mis-incorporated by DNA polymerase? How does DNA polymerase's prootreading domain detect and remove mis-incorporated bases? What does this improve the error rate to? 19. Describe helicase's structure and function, and the role ATP has on its tertiary structure. 29. Define the function of the following at the replication fork: a. Sliding clamp: b. Sliding clamp loader: Sliding clamp loader's t protein (both functions): C. Compare/contrast the traditional vs. newer hypotheses on DNA replication. 22.1f E. coli incorporated the wrong base during replication, how would it differentiate the original from the new strand for repair? 23. How does Cdk regulate DNA replication? 24. Why do the telomeres shorten with each replication? Which cell types have telomerase to lengthen them? 25. How does telomere length relate to aging and disease? What is the Hayflick Limit and how does it relate to telomeres and aging? 26. What are the advantages of sexual reproduction over asexual reproduction? Chapter 10: 27. Explain DNA mutation with regards to its impact, both positive and negative, on humans. Discuss mutations in intergenic DNA vs. exons, and the potential impact of each. 28. Why do RNA viruses have a higher mutation rate than humans? How might this benefit them? 2 Regarding human mutation rates: How can mitochondrial DNA be used to track lineages? b. Does any paternal mitochondria get passed on to children? c. How can the Y chromosome be used to track lineages? d. When did the common ancestor of everyone alive today live? a. How do mutations and SNPS differ? What is the impact of each on an organism?

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
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The Replication of DNA 283 (Concinued). Chapter 9: P molecule ding. es DNA polymerase monitor the incoming base to ensure proper base pairing? How does it prevent RNA from being incorporated? what are some of the ways antiviral and anticancer agents can affect DNA synthesis? How y How often are bases mis-incorporated by DNA polymerase? How does DNA polymerase's prootreading domain detect and remove mis-incorporated bases? What does this improve the error rate to? 19. Describe helicase's structure and function, and the role ATP has on its tertiary structure. 29. Define the function of the following at the replication fork: a. Sliding clamp: b. Sliding clamp loader: Sliding clamp loader's t protein (both functions): C. Compare/contrast the traditional vs. newer hypotheses on DNA replication. 22.1f E. coli incorporated the wrong base during replication, how would it differentiate the original from the new strand for repair? 23. How does Cdk regulate DNA replication? 24. Why do the telomeres shorten with each replication? Which cell types have telomerase to lengthen them? 25. How does telomere length relate to aging and disease? What is the Hayflick Limit and how does it relate to telomeres and aging? 26. What are the advantages of sexual reproduction over asexual reproduction? Chapter 10: 27. Explain DNA mutation with regards to its impact, both positive and negative, on humans. Discuss mutations in intergenic DNA vs. exons, and the potential impact of each. 28. Why do RNA viruses have a higher mutation rate than humans? How might this benefit them? 2 Regarding human mutation rates: How can mitochondrial DNA be used to track lineages? b. Does any paternal mitochondria get passed on to children? c. How can the Y chromosome be used to track lineages? d. When did the common ancestor of everyone alive today live? a. How do mutations and SNPS differ? What is the impact of each on an organism?
Transcribed Image Text:The Replication of DNA 283 (Concinued). Chapter 9: P molecule ding. es DNA polymerase monitor the incoming base to ensure proper base pairing? How does it prevent RNA from being incorporated? what are some of the ways antiviral and anticancer agents can affect DNA synthesis? How y How often are bases mis-incorporated by DNA polymerase? How does DNA polymerase's prootreading domain detect and remove mis-incorporated bases? What does this improve the error rate to? 19. Describe helicase's structure and function, and the role ATP has on its tertiary structure. 29. Define the function of the following at the replication fork: a. Sliding clamp: b. Sliding clamp loader: Sliding clamp loader's t protein (both functions): C. Compare/contrast the traditional vs. newer hypotheses on DNA replication. 22.1f E. coli incorporated the wrong base during replication, how would it differentiate the original from the new strand for repair? 23. How does Cdk regulate DNA replication? 24. Why do the telomeres shorten with each replication? Which cell types have telomerase to lengthen them? 25. How does telomere length relate to aging and disease? What is the Hayflick Limit and how does it relate to telomeres and aging? 26. What are the advantages of sexual reproduction over asexual reproduction? Chapter 10: 27. Explain DNA mutation with regards to its impact, both positive and negative, on humans. Discuss mutations in intergenic DNA vs. exons, and the potential impact of each. 28. Why do RNA viruses have a higher mutation rate than humans? How might this benefit them? 2 Regarding human mutation rates: How can mitochondrial DNA be used to track lineages? b. Does any paternal mitochondria get passed on to children? c. How can the Y chromosome be used to track lineages? d. When did the common ancestor of everyone alive today live? a. How do mutations and SNPS differ? What is the impact of each on an organism?
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