The Mechanism of Action of Cyclophosphamide and its toxicity
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The Mechanism of Action of Cyclophosphamide and its toxicity
reference :http://dx.doi.org/10.3390/scipharm88040042 (reseach paper DOI plz answer in detail do not give short answer )
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- Lung Cancer Patient Whats the use of the given medications below: ● Cisplatin100 mg/m2 IV q4 weeks● Trametinib Dimethyl Sulfoxide 2mg/tab 1 tablet OD● Roflumilast 500 mcg PO● Spiriva Respimat: 5 mcg (2 actuations; 2.5 mcg/actuation)● Budesonide 1 neb q6hr● Hydrochlorothiazide 25 mg tab PO OD● Levothyroxine 175 mcg PO OD● Hydralazine 50 mg tab PO TID● Metformin 500 mg tab PO BIDBased on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives. The given question to me is: What is a pharmacopeial monograph? Based on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives.A patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…
- Do not include zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed dosages factors. Order: Rocephin 500 mg IM Supply: Rocephin 1 gram Directions: Reconstitute with 2.1 mL of sterile water to yield 350 mg/mL Give: ML Moving to another question will save this response. Type here to search O E M 90 DELLDescription of clinical trial process for the Pfizer-BioNTech. Incorporate the following key words: Length of trial; population diversity; efficacy; side effects Pfizer-BioNTechGive typed full explanation Methyldopa is ordered for a pediatric patient at a dose of 450 mg IV q 6 hr. The safe dose range is 20-40 mg/kg/day. The patient weighs 21 kg. Is this medication order safe?
- What is the purpose of an emulsifyingagent? List atleast 5 examples used inpharmaceutical emulsions.Read this article and answer the following question There are 3 different Metformin ER products available: Glucophage XR Glumetza ER Fortamet ER All 3 formulations are available generically but they are not interchangeable as they all use different release mechanisms. Glucophage XR uses a dual hydrophilic polymer system. The drug is slowly released by diffusing through a gel matrix, also known as GelShield diffusion system. Once the tablet is swallowed, the outer layer of the tablet forms a gel layer and the metformin contained within is slowly released. Due to this release mechanism, Glucophage XR can not be cut or split. Glumetza ER uses a mechanism known as gastro-retentive technology (also known as 'Modified Release'). The tablets are designed to remain in the stomach and deliver metformin to the upper GI tract over an extended period of time. Like Glucophage XR, Glumetza ER can not be cut or split. Fortamet ER uses single-composition osmotic technology (SCOT). After…Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity?
- Lophotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.DO NO INC de zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed factors. Order: Monocid 500 mg Supply: Monocid 1,000 mg Directions: Reconstitute with 2.5 mL of sterile water to yield 325 mg/mL Give: mL 4. Moving to another question will save this response. Type here to search EO 9Cimetidine is used in the treatment and management of gastric ulcers and gastroesophageal reflux disease. In the case of an active ulcer, cimetidine can be administered continuous by IV infusion at a dose rate of 37.5 mg/hr. If the concentration of the cimetidine solution is 6 mg/ml, then how many milliliters must be available for a 4-hr infusion?Misoprostol is used to prevent NSAID-induced gastric ulcers. A daily dose consists of two tablets administered four times each day. What is the size of one day’s dose if each tablet contains 100 mcg of misoprostol?