The figure below shows the characteristic pattern of Ca2+ influx in the red line (wild-type; WT), where TCR stimulation causes a sharp rise in cytoplasmic Ca2+, followed by a slow decline over hours. As shown below, cytoplasmic Ca2+ concentrations do not normally return to baseline for the time course of this experiment. A mutant mouse is identified with a defect in T cell activation in response to TCR stimulation. The calcium response of T cells from the mutant mouse is shown in the blue line. a) Given these data, name three T cell signaling proteins that could be defective in the mutant T cells.
The figure below shows the characteristic pattern of Ca2+ influx in the red line (wild-type; WT), where TCR stimulation causes a sharp rise in cytoplasmic Ca2+, followed by a slow decline over hours. As shown below, cytoplasmic Ca2+ concentrations do not normally return to baseline for the time course of this experiment. A mutant mouse is identified with a defect in T cell activation in response to TCR stimulation. The calcium response of T cells from the mutant mouse is shown in the blue line.
a) Given these data, name three T cell signaling proteins that could be defective in the mutant T cells.
b) Name three T cell signaling proteins that could not be responsible for this defect, even if mutated.
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