The citric acid cycle converts each acetyl-CoA to [1/2/3/4] molecules of CO2. This pathway is considered [catabolic/anabolic] because it breaks down acetyl-CoA into smaller molecules and [catabolic/anabolic] because the intermediates are building blocks for other metabolites in the cell. The citric acid cycle produces [1/2/3] NADH and [1/2/3] FADH2 for every acetyl-CoA consumed. help fill in the blanks
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The citric acid cycle converts each acetyl-CoA to [1/2/3/4] molecules of CO2. This pathway is considered [catabolic/anabolic] because it breaks down acetyl-CoA into smaller molecules and [catabolic/anabolic] because the intermediates are building blocks for other metabolites in the cell. The citric acid cycle produces [1/2/3] NADH and [1/2/3] FADH2 for every acetyl-CoA consumed.
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- Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is inhibited by· NIADH. Pyruvate dehydrogenase is inhibited by AΤΡ. Citrate synthase is inhibited by NADH. Succinyl-CoA activates citrate synthase. Acetyl-CoA activates pyruvate carboxylase.The citric acid cycle is a critical sequence of reactions for energy production, which take place in the matrix of the mitochondria. The reaction cycle requires materials from the cytosol to be converted into acetyl CoA, which represents the starting point of a new cycle. Which of the following statements about acetyl CoA is true? (a) Acetyl CoA is recycled at the end of every cycle. (b) Oxaloacetate is attached to acetyl CoA to feed the citric acid cycle. (c) Triacylglycerol molecules are transported into the mitochondrial matrix and cleaved by lipases to produce acetyl CoA. (d) Oxaloacetate is converted directly into acetyl CoA to feed the citric acid cycleThe citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options except citrate. Which carbon in citrate will contain C14? 4 1 3 2 Which carbon(s) in isocitrate will contain C14? 1 2 3 4 5 6 Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4
- The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, please choose more than one. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, answering with only one option is incorrect. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4There are eight chemical reactions that occur in the citric acid cycle process. The reactions of the citric acid cycle are shown in the figure below. acetyl-coenzyme A 0 CH₂-C-CoA HO-CH Reaction 7 O malate CH₂ CH || CH fumarate FADH₂ Reaction 6 FAD H+ + NADH NAD+ 1,0 H₂C CH₂ CH₂ Reaction 8 succinate ADP 0=C GTP CH₂ oxaloacetate Reaction 5 H-COA GDP ATP H₂O Reaction 1 C Reactions of the Citric Acid Cycle CH₂ CH₂ H-COA 0=C 1 CoA succinyl-CoA H+ HO-C Reaction CO₂ с CH₂ NADH CH₂ citrate Reaction 2 H-COA Reaction 3 CO₂ I CH₂ T CH₂ 0=C NAD+ HO–CH a-ketoglutarate CH, CH isocitrate NAD+ H+ + NADH In chapters 9 and 10, you were introduced to several classes of organic reactions. These classes include esterification, decarboxylation, hydration reactions, dehydration of alcohols, oxidation of alcohols, oxidation of aldehydes, reduction of aldehydes, and reduction of ketones. Find at least one of these reaction classes in the citric acid cycle. List the reaction number and the reaction. Write a…
- Which of the following statements is/are TRUE for the Krebs' cycle? Reaction 1: condensation of acetyl-CoA and oxaloacetate; produces H20. Reaction 3: oxidation of isocitrate to a-ketoglutarate; produces NADH and CO2. Reaction 6: oxidation of succinate to fumarate; produces FADH2 and CO2 Reaction 5: hydrolysis of succinyl-CoA to succinate; produces ATP.The CO2 produced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. (a) How many rounds are required before 14CO2 is released if acetyl-CoA is labeled at its methyl group? (b) If acetyl-CoA is labeled with 14C at its carbonyl carbon, how many rounds of the cycle are required before 14CO2 is released?Malate synthase, an enzyme of the glyoxylate cycle, catalyzes the condensa- tion of glyoxylate with acetyl-CoA. Which enzyme of the citric acid cycle carries out a similar reaction? Would you expect the binding of glyoxylate and acetyl-CoA to malate synthase to be sequential? Why?
- When the acetyl-CoA produced during B-oxidation in the liver exceeds the capacity of the citric acid cycle, the excess acetyl-CoA forms ketone bodies-acetone, acetoacetate, and D-b-hydroxybutyrate. This occurs in severe, uncontrolled diabetes: because the tissues cannot use glucose, they oxidize large amounts of fatty acids instead. Although acetyl-CoA is not toxic, the mitochondrion must divert the acetyl-CoA to ketone bodies. What problem would arise if acetyl-CoA were not converted to ketone bodies? How does the diversion to ketone bodies solve the problem?When the acetyl-CoA produced during β-oxidation in the liver exceeds the capacity of the citric acid cycle, the excess acetyl-CoA forms ketone bodies—acetone, acetoacetate, and D-b-hydroxybutyrate. This occurs in severe, uncontrolled diabetes: because the tissues cannot use glucose, they oxidize large amounts of fatty acids instead. Although acetyl-CoA is not toxic, the mitochondrion must divert the acetyl-CoA to ketone bodies. What problem would arise if acetyl-CoA were not converted to ketone bodies? How does the diversion to ketone bodies solve the problem?How many acetyl CoA molecules are produced in one cycle of beta oxidation? How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units? a)How many acetyl CoA molecules would be produced? b) How many reduced nucleotides would be produced? c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.