None Substrates containing Evan's auxiliary could be used not only for the asymmetricalkylation or aldol reactions, but also for the asymmetric Diels-Alder reaction. Please use yourknowledge of the Evan's auxiliarie's to predict the main diastereomer of this reaction. Hint:Et2 AICI acts as a chelating LA here.MeN..Et₂AICI (2 eq)-78 °C, >99:1 dr(provide stereochemistry)i-Pr

The question asks students to predict the main diastereomer of an asymmetric Diels-Alder reaction…

Answered: Substrates containing Evan's auxiliary…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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resource from Cengage Learning - Google Chrome ssignment/takeCovalentActivity.do?locator=assignment-take e by the Aldol Condensation (References) OH base + H,0 heat H. H3C H. The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a B-hydroxy carbonyl compound. In the mixed aldol reaction, the best results are obtained when one of the partners does not have an a-hydrogen. It cannot form an enolate anion and can therefore not undergo self-reaction. The enolizable aldehyde is added slowly to a basic solution of the first aldehyde so that the mixed product is preferentially formed. Under reaction conditions slightly more vigorous…
Show Transcribed Text H₂, Pd/C, EtOH MeMgBr (excès) puis H3O+ Me₂CuLi, Et₂O puis H₂O+ Please draw the mechanism step by step ? ? ?
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