Some mucosal barriers prevent part of the viral particles to penetrate the respiratory epithelium. Which are these barriers and how do they act?
In December 2020, Jean, a 30 year-old man, went to a concert in his town where more than 3 thousand people attended. Only 30% of the people in the concert were wearing mask, and there was not enough space to keep social distance. After 6 days, Jean started to develop fever and he lost the sense of smell and taste. Eight days after the party, he began to have difficulty breathing and was diagnosed with COVID-19. Let’s try to write the whole story about how the SARS-CoV2 invaded Jean’s body.
SARS-CoV2 viral particles entered Jean’s nasal cavity and attached to the respiratory mucous membranes.
- Some mucosal barriers prevent part of the viral particles to penetrate the respiratory epithelium. Which are these barriers and how do they act?
2) Which cells are recruited from the bloodstream to the connective tissue (under the respiratory epithelium) to phagocyte the viral particles? Explain the recruitment mechanism.
After a few days of the infection, Jean’s adaptive immune system is ready to attack the remaining viral particles that were not efficiently destroyed by the innate immunity army.
3) Explain one mechanism of antibody action against viruses.
4)Is it possible for the immune system to eliminate the viruses without B cells? Why or why not? (This question will be graded based on your ability to think critically – even if the event described is not realistic.)
The T cell response follows the antibody-mediated B cell immunity.
5)What is the connection between B and T cells to build an effective immune response to SARS-Cov2?
6)Is it possible for the immune system to eliminate the viruses without T cells? Why or why not? (This question will be graded based on your ability to think critically – even if the event described is
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