Select one or more: a. Maternal IgG transferred across the placenta b. Maternal dimeric IgA transferred by breast feeding c. Newly synthesized IgM from infant exposure to antigens d. Maternal IgM transferred across the placenta e. Maternal IgE transferred by breast feeding
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- A newborn has a positive DAT using anti-IgG AHG. An antibody screen is performed on the newborn's serum and is negative. The newborn forward types as A positive while the mother is O Positive. Explain two possibilities for this result. What is your next step?Organ Transplants Must Be Immunologically In the human HLA system there are 23 HLA-A alleles, 47 for HLA-B, 8 for HLA-C, 14 for HLA-DR, 3 for HLA-DQ, and 6 for HLA-DP. How many different human HLA genotypes are possible?Draw a picture of how antihuman globulin (AHG) helps agglutination when IgG antibodies are involved
- The majority of vaccines work by eliciting pathogen-specific antibodies that circulate in our bodies and protect us in the event that we are later exposed to that specific pathogen. For most viruses and bacterial toxins that we are vaccinated against, these pre-existing antibodies are protective because They induce mucus production that helps flush the toxin or virus out of the body They bind to the virus or toxin and carry it to the liver where it can be degraded O They neutralize the virus or toxin, preventing it from attaching to and entering our cells They bind to epithelial cells and induce the production of antimicrobial peptidesWhich of the following mothers is MOST Likely to have a child with hemolytic disease of the newborn? b. Group AB, R1R1 with anti-Lu(a) c. Group B, R2R2 with anti-e d. Group A1, R1r with anti-HA 1-day old Caucasian male neonate was born to a 24-year old gravida 1 female at 37 weeks gestational age via Caesarian section, secondary to failure to progress in labor. The infant was delivered without complications. Routine blood work on the infant revealed an unexpected red cell antibody. A DAT and antibody screen were both noted to be positive. a. The mother and neonate share the same antibody identification panel. Why? Defend your answer.
- If David is given prednisone, a synthetic glucocorticoid, for a prolonged period of time, he may: A. develop signs of Cushing's disease B. both develop signs of Cushing's disease and become immunocompromised C. develop signs of Cushing's syndrome D. both develop signs of Cushing's syndrome and become immunocompromised E. become immunocompromisedWould the same procedure of MIC can be applicable in determining allergies in man?In some cases of weak D antigen testing, the interpretation of results can reveal that the person tested is somewhat D+ and D- at the same time. How is this possible? What is/are the implication/s of this Rh phenotyping result in the blood donation and transfusion of the said person?
- 8) In addition to the ABO self-antigen system, another red blood cell self-antigen system is the Rh factor. The gene for this self=antigen system exhibits complete dominance with Rh positive (the presence of self-antigen Rh) being completely dominant over Rh negative (the absence of the self-antigen Rh). Rh positive is symbolized as + and Rh negative is symbolized as -. a. Geraldo has B- blood and Arline has O+ blood. Geraldo’s father has B+ blood and his mother has O- blood. Arline’s mother has O= blood and her father has A+ blood. Geraldo and Arline have a daughter, Elise. Using a Punnett square, what are the possible blood types for Elise? b. What is Geraldo’s genotype? c. What is Arline’s genotype?An A negative mother (gravida 5, para 5) has just delivered an A positive newborn. Her antibody screen is positive and a panel shows the antibody is anti-D. The anti-D titer is 8. The child has a positive DAT. How could you determined how many doses of Rh immune globulin should be given to this mother?The class of immunoglobulins which can cross the placenta is -