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- 5-6. Choose the best answer from the following questions and provide a one paragraph explanation for your response. 5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate A. Glucose ? B. Oxaloacetate C. acetyl-CoA D. Lactate Explanation for answer in no. 5: 6. In the RBCS of the patient described above, which of the following would be expected A. ADP to ATP ratios would be elevated above normal. B. NADP+ would increase relative to NADPH. ? C. Ribulose 5-phosphate levels would decrease. D. NADH to NAD+ ratios would decrease. E. Methemoglobin levels would increase. Explanation for answer in no. 6:Since in this patient, pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Question is, which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? Explain.QUESTION: Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? A. Glucose B. Oxaloacetate C. acetyl-CoA D. Lactate CASE STUDY # 2 A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a "blood problem" in her family but doesn't know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. BIOCHEMICAL MECHANISM: Pyruvate kinase deficiency usually will manifest clinical…
- Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? a. Glucose b. Oxaloacetate c. acetyl-CoA d. Lactate How does RBC's having no mitochondria do with this?Please answer true or false and give explanation. Thank you 4. The coenzyme of monoamine oxidases (MAO) is FAD. 5. Decarboxylation of amino acids is an irreversible process. 6. Does histamine have a vasoconstrictive effect?Which LDH isoenzyme is elevated in myocardial infarction? Explain why. What LDH isoenzyme can be use as a liver function test? Explain why.
- Multiple answer question. SELECT ALL THAT APPLY. Which of the following is associated with an increase in hematocrit? Hemophilia O Low WBCS (white blood cells) Anemia Dehydration OIncrease in erythropoietin O Decrease in thrombopoietin • PreviousCase 3// laboratory results for patients with uncontrolled type 1 DM reveal hyperglycemia (456 mg/dl) and hyper triglyceridemia ( 395 mg/dl), the most likely cause of the hyper triglyceridemia in this patients is which of the following ? 1. Deficiency in a apoprotein C-II 2. Increased hepatic TGs synthesis 3. Decreased lipoprotein lipase activity 4. Deficiency in LDL receptors5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates above pyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not be made in the appropriate amounts in the RBC because of the deficiency of pyruvate? A.Glucose B.Oxaloacetate C.acetyl-CoA D.Lactate Explanation for answer in no. 5: 6.In the RBCS of the patient described above, which of the following would be expected? A.ADP to ATP ratios would be elevated above normal. B.NADP+ would increase relative to NADPH. C.Ribulose 5-phosphate levels would decrease. D.NADH to NAD+ ratios would decrease. E.Methemoglobin levels would increase
- Could you please answer this question. Thanks so much. What is the ventilator order for this patient? Defend your answer. Patient Barry King is a 27-year-old, asthma patient with COVID-19, who now needs Mechanical ventilation due to respiratory failure related to complications from COVID. He currently weighs 75kg. His current vitals are as follows: RR-24, Breath sounds- coarse crackles in both lungs. His temperature is 102.3, BP- 152/100, HR- 115 bpm, FiO2 on 50% high flow oxygen and ABG results are:pH- 7.29, PACO2-58, PAO2-49, HCO3-23. The MD wants you to suggest ventilator orders for RT to carry out. Please write reasonable orders and defend your order (include Vt, RR, Mode, PEEP, FiO2 and other procedures or orders that would help).Exaplin in detail. Aplastic anemia Iron deficiency anemia Sickle cell anemia Thalassemia how are they casues the outcomes. How ot they effect the heart and lungdeficiency of vitamin B12 or folate can be result in * Sickle cell anemia Megaloblastic anemia Thalassemia Pernicious anemia