Pilocarpine is a medication used in eye drop to manage angle closure glaucoma. It works by activating cholinergic receptors of the muscarinic type which cause the trabecular meshwork to open and the aqueous humor to drain from the eye. The diester compound in the left can serve as a prodrug for pilocarpine. Please provide a mechanism for this conversion using esterase.
Pilocarpine is a medication used in eye drop to manage angle closure glaucoma. It works by activating cholinergic receptors of the muscarinic type which cause the trabecular meshwork to open and the aqueous humor to drain from the eye. The diester compound in the left can serve as a prodrug for pilocarpine. Please provide a mechanism for this conversion using esterase.
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section: Chapter Questions
Problem 18.42P
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