Of the following statements related to the function of telomeres, identify which is FALSE. a. Telomeres protect organisms from cancer by limiting the number of somatic cell divisions b. Telomeres help prevent unnecessary cell death by preventing DNA monitoring activity at the staggered ends of DNA c. Telomeres restore the length of lagging DNA strands in germ cells d. Telomeres offer some protection against the unavoidable shortening of genes

Of the following statements related to the function of telomeres, identify which is FALSE. a. Telomeres protect organisms from cancer by limiting the number of somatic cell divisions b. Telomeres help prevent unnecessary cell death by preventing DNA monitoring activity at the staggered ends of DNA c. Telomeres restore the length of lagging DNA strands in germ cells d. Telomeres offer some protection against the unavoidable shortening of genes

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter14: Antineoplastic Drugs

Section: Chapter Questions

Problem 11CRQ

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Which of the following are characteristics of aging cells (select all that apply)? A. Chronic inflammation results in premature shortening of telomeres B. Lengthening of telomeric DNA sequence C. Accumulation of telomere-dysfunction–induced foci (TIFs) D. Older cells produce more telomerase E. Increased erosion of telomeres
Explain the Role of telomere in regards to cancer
Write the word TRUE if the statement is correct and if false, replace the underlined words with the correct one. 1. Heterochromatin is typically gene-rich and composed of loosely-packed DNA that is transcriptionally active. 2. Molecular switches regulate the expression of genes by directing where and when genes should be turned on or off depending on the cell signal. 3. DNA Methylation and acetylation of histones are inverselycorrelated 4. Specialized cells produce specialized proteins derived from luxury genes which are constitutively expressed. 5. In mammals, methylation patterns that regulate DNA structure and gene expression become evident from the gastrula stage.
Think about the important functions of telomeres. Now, imagine a scenario in which a mutant eukaryotic cell DID NOT have such specialized telomeric regions present on its chromosomes. List three major CONSEQUENCES of the lack of telomeres, based upon what you know about their normal functions.
Which of the following represents the order of increasingly higher levels of organization of chromatin? Select one: O a. looped domain, nucleosome, 30-nm chromatin fiber O b. 30-nm chromatin fiber, nucleosome, looped domain C. nucleosome, looped domain, 30-nm chromatin fiber O d. looped domain, 30-nm chromatin fiber, nucleosome nucleosome, 30-nm chromatin fiber, looped domain е.
(b): How many forms can naturally occurring DNA exist in? Explain how these forms are characterized. What properties of the functional groups determine the binding of DNA with anti-cancer agents? Explain.
Answer the following questions about telomeres: 1. What are telomeres? 2. Why are telomeres necessary? 3. Why do prokaryotic cells not have telomeres?
A cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true? a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed. b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone. c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression. d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.
Think about the important functions of telomeres. Now, imagine a scenario in which a mutant eukaryotic cell DID NOT have such specialized telomeric regions present on its chromosomes. List three major CONSEQUENCES of the lack of telomeres, based upon what you know about their normal functions. Please clearly list 3 consequences
What is the impact of telomere length on the rate of cell division and cellular aging?
New treatments for several conditions are being developed using stem cells in medical waste, such as biopsy material, teeth, menstrual blood, umbilical cords, and fatty tissue removed in liposuction. For example, fat samples from injured horses are used to grow stem cells to treat tendon injuries. Explain how the two defining characteristics of stem cells enable them to be used to replace damaged or diseased tissue, so that the new tissue functions as opposed to forming a scar.
Explain Telomere cell maintenance

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	a.	Telomeres protect organisms from cancer by limiting the number of somatic cell divisions
	b.	Telomeres help prevent unnecessary cell death by preventing DNA monitoring activity at the staggered ends of DNA
	c.	Telomeres restore the length of lagging DNA strands in germ cells
	d.	Telomeres offer some protection against the unavoidable shortening of genes