How can having the heterozygous form of the Tay Sachs genotype be a blessing? O It may protect against TB. O It diminishes the pain caused by sickle cell anemia. O Harmful genes cannot be passed to the next generation. O Babies always die before they have a chance to grow up and reproduce.
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- If your father were diagnosed with an inherited disease that develops around the age of 50, would you want to be tested to find out whether you would develop this disease? If so, when would you want to be tested? As a teenager or sometime in your 40s? If not, would you have children?A mutation that occurs to a bone marrow stem cell (restocks blood cells) in an adult individual is heritable to all the cells that are descended from it but is not passed on to their future children. O True False➡ Listen Jimmy has type B blood and his mother has type O blood. What must Jimmy's genotype be? B|B |Bi OBIB or Bi Neither IBIB nor |Bi ➡) Listen Two parents have type AB blood. What is the chance that they have a child with type B blood? (just write the number; if the answer was "37 percent" you would just write 37.) ➡ Listen Two parents have type AB blood. What is the chance that they have a child with type AB blood? (just write the number; if the answer was "37 percent" you would just write 37.)
- Achondroplasia is a form of dwarfism in humans. It is caused by a mutant allele of the fibroblast growth factor receptor 3 gene ( FGFR3) that produces an overactive protein. Having one copy of the mutant allele results in dwarfism. Two copies of the mutant allele results in death before birth. If a man with Achondroplasia marries a woman who is Sickle Cell Anemia carrier and they have a child together, what is the probability that their child will Achondroplasia AND be a Sickle Cell Anemia carrier? ½ 2/3 ¼ 1 ½ 1/16Sickle anemia is a favorable mutation. There is only one amino acid different in sickle haemoglobin (S) as compared with normal haemogloblin (A). Persons with sickle cell trait (AS) are able to survive in malarious areas. A couple each having sickle cell trait have five children. What is the probability that they will have a child with sickle disease?Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and 11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28th Her sister, who married an unaffected man, has two affected sons and a normal daughter. You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation. What is the risk (probability) that the fetus is affected? Amniocentesis has to be performed in order to determine the sex of the fetus. What is the risk that the child will be…
- Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). a. Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation. b. What is most likely the pattern of inheritance for this condition? c. Justify your answer in letter (b).d. What is the risk (probability) that the fetus is affected?…Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28 th year. Her sister, who married an unaffected man, has two affected sons and a normal daughter.You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD).II 2 III 1 Refer to the pedigree above. What is the genotype of person II-1 if this pedigree is for hemophilia? (A dot in the centre of a symbol indicates a known carrier of a recessive trait). hh O xtxh Hh O xhy OxHy
- In humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won’t ever be carriers). X H X H = female, non-hemophilic X H X h = female, carrier X h X h = female, hemophilia X H Y = male, non-hemophilic X h Y= male, hemophiliac a.) Show the cross of a man who has hemophilia with a woman who is a carrier. What is the probability that their children will have the disease? b.) A woman who is a carrier marries a non-hemophilic man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? c.) A woman who has hemophilia marries a non-hemophilic man. How many of their children will have hemophilia, and what is their sex?Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.) A) None of their children will have sickle-cell disease. B) All of their children will have sickle-cell disease. C) All of the couple's children would be heterozygous carriers like the mother.