How are mutations in histone acetylation (HAT) genes linked to cancer?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter12: Genes And Cancer
Section: Chapter Questions
Problem 9QP: What is the difference between a proto-oncogene and a tumor-suppressor gene?
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How are mutations in histone acetylation (HAT) genes linked to
cancer?

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HATs or histone acetyltransferase are enzymes that acetylate the lysine amino acid on histone proteins. This is done by transferring the acetyl group from acetyl-CoA to form N-acetyl lysine. By transfer of acetyl group to histones, DNA is wrapped around the histones.

 

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