Grignard reactions are often limited by steric hindrance. While Grignard reagents react in high yield with ethylene oxideand monosubstituted epoxides, yields are often lower with disubstituted epoxides. Tri- and tetrasubstituted epoxides reactwith difficulty, if at all.(a) Show how to make these alcohols by a Grignard reacting with an epoxide.
Grignard reactions are often limited by steric hindrance. While Grignard reagents react in high yield with ethylene oxideand monosubstituted epoxides, yields are often lower with disubstituted epoxides. Tri- and tetrasubstituted epoxides reactwith difficulty, if at all.(a) Show how to make these alcohols by a Grignard reacting with an epoxide.
Chapter16: Chemistry Of Benzene: Electrophilic Aromatic Substitution
Section16.SE: Something Extra
Problem 74AP: Identify the reagents represented by the letters a-e in the following scheme:
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Grignard reactions are often limited by steric hindrance. While Grignard reagents react in high yield with ethylene oxide
and monosubstituted
with difficulty, if at all.
(a) Show how to make these alcohols by a Grignard reacting with an epoxide.
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