Good evening, Could you write me an abstract for the Dependance of Distribution Coefficient Upon pH? Even if its just the first paragraph. There is an example one ive attached below.
Good evening, Could you write me an abstract for the Dependance of Distribution Coefficient Upon pH? Even if its just the first paragraph. There is an example one ive attached below.
Chapter16: Applications Of Neutralization Titrations
Section: Chapter Questions
Problem 16.7QAP
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Good evening,
Could you write me an abstract for the Dependance of Distribution Coefficient Upon pH? Even if its just the first paragraph.
There is an example one ive attached below.
Please help me. ❤️❤️?
![Downlo
Abstract
The partition coefficient (P) or distribution coefficient (D) is a ratio that compares the
solubilities and distribution of a solute between two immiscible solvents. It gives an
indication of whether that substance is lipophilic (tends towards the non-polar phase) or
hydrophilic (favours the water). If logP is less than 0, the drug partitions more into
hydrophilic areas whereas if logP is greater than 0, the drug partitions more into lipophilic
areas.
The aim of this experiment was investigating and determining the effect of the pH of a
solution on the distribution coefficient of a drug, in this case benzoic acid. In order to carry
out this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid in
ethyl acetate was used to prepare standard solutions of varying concentrations whose
absorbances were measured to produce a calibration plot. A biphasic liquid of stock solution
and pH 6.0 buffer was produced and the absorbance was then recorded and used to
calculate the distribution coefficient of benzoic acid at this pH. The process then repeated
using pH 7.0 buffer.
The oH 6.0 buffer solution had resulted in a higher logD value than the pH 7.0 buffer solution:
and pH 8.0. This was because the agueous ohase at pH 7.0 was relative y more alkaline than
at pH 6.0 and so more acid molecules were ionised and so partitioned more into the
aqueous ohase at oH 7.0. The outcome of this experiment wvas therefore determiningE that
benzoic acid ismore lipophilic at pH 6.0 than at pk 7.0 and oH 8.0.
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Transcribed Image Text:Downlo
Abstract
The partition coefficient (P) or distribution coefficient (D) is a ratio that compares the
solubilities and distribution of a solute between two immiscible solvents. It gives an
indication of whether that substance is lipophilic (tends towards the non-polar phase) or
hydrophilic (favours the water). If logP is less than 0, the drug partitions more into
hydrophilic areas whereas if logP is greater than 0, the drug partitions more into lipophilic
areas.
The aim of this experiment was investigating and determining the effect of the pH of a
solution on the distribution coefficient of a drug, in this case benzoic acid. In order to carry
out this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid in
ethyl acetate was used to prepare standard solutions of varying concentrations whose
absorbances were measured to produce a calibration plot. A biphasic liquid of stock solution
and pH 6.0 buffer was produced and the absorbance was then recorded and used to
calculate the distribution coefficient of benzoic acid at this pH. The process then repeated
using pH 7.0 buffer.
The oH 6.0 buffer solution had resulted in a higher logD value than the pH 7.0 buffer solution:
and pH 8.0. This was because the agueous ohase at pH 7.0 was relative y more alkaline than
at pH 6.0 and so more acid molecules were ionised and so partitioned more into the
aqueous ohase at oH 7.0. The outcome of this experiment wvas therefore determiningE that
benzoic acid ismore lipophilic at pH 6.0 than at pk 7.0 and oH 8.0.
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