Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
Glycogen synthase kinase 3 beta (GSK-3ß) is a serine-threonine kinase known for its ability to regulate glycogen synthesis. In addition, it has been reported that GSK-3B plays important roles in many intracellular pathways and numerous pathologies, such as Alzheimer's disease and cancer. Inhibitors have been developed to modulate GSK-3ß activity and used as therapies. The kinetics of the enzyme (GSK-3B) with and without its inhibitor is shown in the plot below. B 1/v (sec/uM) 1/[S) (1/uM) a) Which line indicate the condition with inhibitor, line A or line B? b) What is the type of this inhibitor? Explain. c) Determine Vmax and Km for this enzyme in the inhibited state. Be sure to include the units.

Glycogen synthase kinase 3 beta (GSK-3ß) is a serine-threonine kinase known for its ability to regulate glycogen synthesis. In addition, it has been reported that GSK-3B plays important roles in many intracellular pathways and numerous pathologies, such as Alzheimer's disease and cancer. Inhibitors have been developed to modulate GSK-3ß activity and used as therapies. The kinetics of the enzyme (GSK-3B) with and without its inhibitor is shown in the plot below. B 1/v (sec/uM) 1/[S) (1/uM) a) Which line indicate the condition with inhibitor, line A or line B? b) What is the type of this inhibitor? Explain. c) Determine Vmax and Km for this enzyme in the inhibited state. Be sure to include the units.

Biology 2e
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...
See similar textbooks
icon
Related questions
Question
6. Glycogen synthase kinase 3 beta (GSK-3B) is a serine-threonine kinase known for its ability to regulate glycogen synthesis. In addition, it has been reported that GSK-3B plays important roles in many intracellular pathways and numerous pathologies, such as Alzheimer's disease and cancer. Inhibitors have been developed to modulate GSK-3ß activity and used as therapies. The kinetics of the enzyme (GSK-3B) with and without its inhibitor is shown in the plot below. B 1/v (sec/uM) 1/(S] (1/uM) a) Which line indicate the condition with inhibitor, line A or line B? b) What is the type of this inhibitor? Explain. c) Determine Vmax and Km for this enzyme in the inhibited state. Be sure to include the units.
Transcribed Image Text:6. Glycogen synthase kinase 3 beta (GSK-3B) is a serine-threonine kinase known for its ability to regulate glycogen synthesis. In addition, it has been reported that GSK-3B plays important roles in many intracellular pathways and numerous pathologies, such as Alzheimer's disease and cancer. Inhibitors have been developed to modulate GSK-3ß activity and used as therapies. The kinetics of the enzyme (GSK-3B) with and without its inhibitor is shown in the plot below. B 1/v (sec/uM) 1/(S] (1/uM) a) Which line indicate the condition with inhibitor, line A or line B? b) What is the type of this inhibitor? Explain. c) Determine Vmax and Km for this enzyme in the inhibited state. Be sure to include the units.
Expert Solution
steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
SEE MORE TEXTBOOKS