Gentamicin 340 mg (7 mg/kg/dose) IV q24h regimen. Kinetics calculated to be: Ke calculated to be 0.254 and half-life is 2.73 hours. Cmax (after end of infusion) calculated to be 19.37 mcg/mL. Time undetectable until next dose is about 12.34 hours. Tonight patient had a dose given at 1801 and this ran for 60 minutes. Gentamicin level resulted 9.25 mcg/mL @ 2230. Infectious disease doctor is okay with just doing 3 hr level since time undetectable is of little significance for her indication. Can calculate Cpk with previous Ke. Renal function has improved so no expected toxicity but still want to verify that patient is clearing. Please calculate Cpk and should I keep the regimen as is or change it?
Gentamicin 340 mg (7 mg/kg/dose) IV q24h regimen. Kinetics calculated to be: Ke calculated to be 0.254 and half-life is 2.73 hours. Cmax (after end of infusion) calculated to be 19.37 mcg/mL. Time undetectable until next dose is about 12.34 hours. Tonight patient had a dose given at 1801 and this ran for 60 minutes. Gentamicin level resulted 9.25 mcg/mL @ 2230. Infectious disease doctor is okay with just doing 3 hr level since time undetectable is of little significance for her indication. Can calculate Cpk with previous Ke. Renal function has improved so no expected toxicity but still want to verify that patient is clearing. Please calculate Cpk and should I keep the regimen as is or change it?
Chapter13: Dimensional Analysis/units Conversion
Section: Chapter Questions
Problem 7SST
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Gentamicin 340 mg (7 mg/kg/dose) IV q24h regimen. Kinetics calculated to be: Ke calculated to be 0.254 and half-life is 2.73 hours. Cmax (after end of infusion) calculated to be 19.37 mcg/mL. Time undetectable until next dose is about 12.34 hours. Tonight patient had a dose given at 1801 and this ran for 60 minutes. Gentamicin level resulted 9.25 mcg/mL @ 2230. Infectious disease doctor is okay with just doing 3 hr level since time undetectable is of little significance for her indication. Can calculate Cpk with previous Ke. Renal function has improved so no expected toxicity but still want to verify that patient is clearing. Please calculate Cpk and should I keep the regimen as is or change it?
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