Genes can be silenced through epigenetic changes that occur Genes can be silenced through epigenetic changes that occur at CpG islands located in RNA. at the C-terminus of histone tails. at lysines located in the nucleic acids sequence. at regulatory regions in DNA.
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Genes can be silenced through epigenetic changes that occur
Genes can be silenced through epigenetic changes that occur
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- Epigenetic marks regulate gene expression. Which epigenetic mark is NOT associated with positive gene expression? Histone acetylation Histone Methylation De-methylated DNA Methylated DNAWhich of the following is true about epigenetic modifications? -Epigenetic modifications always repress transcription -Epigenetic modifications are irreversible -Epigenetic modifications only occur on the tails of histone proteins -Epigenetic modifications influence the relationship between DNA and histone proteinsWhich of the following is a method through which cells can control their gene expression? Increase a gene's stability using post-translational modifications Epigenetic modifications of the DNA or histones to regulate DNA avilability phosphorylation of thymidines formation of crosslinks between the DNA strands and the histones
- Possible genetic modifications that can cause epigenetic changes in gene expression include: A- all answers are correct B- histone acetylation C- chromatin remodeling D- histone variant localization  e- DNA methylationThe diagram below shows the structure of DNA from the level of a gene to a condensed mitotic chromosome. At each of the four locations marked, indicate how a gene may be regulated by selecting from the choices given. Some answer choices may fit into more than one position; however, you should use each answer choice only once. Choices given: Alternative splicing within the gene sequence can lead to different forms of mRNA. A promoter region can be blocked by another protein. Histone deacetylation can prevent DNA from unwinding. A regulatory region can be bound and increase transcription rates.Epigenetic changes in gene regulation are caused by ________. missing nucleotides or chromosomes missing nucleotides or chromosomes mutations of the nucleotide sequence mutations of the nucleotide sequence modifications to histones and the DNA, but not the nucleotide sequence itself
- Epigenetic phenomena involve DNA methylation and histone acetylation genetic mutation chromosomal rearrangements gene inversionsA disease is caused by having no functional protein produced from the kip gene. An individual has this disease but has no mutation in the kip gene. You look at other gene candidates that could result in no functional kip protein. A gene called D5 codes for a methyltransferase that methylates the kip promoter region. A gene called T3 codes for an acetylase that acetylates the histones in the region of the kip gene. Fill in the following blanks. In the situation described above, in which no kip protein is made, it is likely that the D5 gene has a mutation that ___________ the D5 protein or that the T3 gene has a mutation that ___________the T3 protein. Blanks can either be deactivates or activatesHydrogen bonds are important in DNA replication and transcription. They are relatively weak chemical bonds. Why is this a desirable feature for DNA? Describe the effect (s) of changing (mutating) the promoter on the transcription of the DNA strand/gene the promoter controls. What happens to protein synthesis if a nonsense codon is inserted into the gene? Explain why a point mutation does not necessarily change the original amino acid sequence. (Explain silent mutations) Choose any pentapeptide composed of five different amino acids. List the amino acids. Present one messenger RNA codon for each amino acids and the sequence of nucleotides on the DNA that originally coded for your pentapeptide.
- In your own words, explain epigenetics. What is it? What are the main epigenetic marks? What do they do in terms of gene transcription? What are the enzymes involved?The following is true about epigenetic gene control: O epigenetic changes to the chromatin may result from childhood development epigenetic changes to the chromatin may result from chemicals in the environment O epigenetic changes to the chromatin may result in cancer O An example of a chromatin change is DNA methylation that prevents gene expression from that area of the DNAPositive and negative regulator proteins that bind to enhancer regions of the DNA and stimulate or inhibit transcription in eukaryotes are known as: translation inhibitors. translation regulators. special transcription factors. basal transcription factors.