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Experimental measurements of the reversible interaction between a drug and its receptor show k.=0.005 min and K, = 16 pM. a) Write the reaction scheme. b) Calculate the binding half-lives in solutions with drug concentrations of 1, 10, 100, and 1000 pM. c) Plot the half-life vs drug concentration, and explain how drug concentration affects binding kinetics at very low and very high concentrations.

Experimental measurements of the reversible interaction between a drug and its receptor show k.=0.005 min and K, = 16 pM. a) Write the reaction scheme. b) Calculate the binding half-lives in solutions with drug concentrations of 1, 10, 100, and 1000 pM. c) Plot the half-life vs drug concentration, and explain how drug concentration affects binding kinetics at very low and very high concentrations.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Problem 4 (20 points) Experimental measurements of the reversible interaction between a drug and its receptor show k,=0.005 min and Ko = 16 pM. a) Write the reaction scheme. b) Calculate the binding half-lives in solutions with drug concentrations of 1, 10, 100, and 1000 pM. c) Plot the half-life vs drug concentration, and explain how drug concentration affects binding kinetics at very low and very high concentrations.
Transcribed Image Text:Problem 4 (20 points) Experimental measurements of the reversible interaction between a drug and its receptor show k,=0.005 min and Ko = 16 pM. a) Write the reaction scheme. b) Calculate the binding half-lives in solutions with drug concentrations of 1, 10, 100, and 1000 pM. c) Plot the half-life vs drug concentration, and explain how drug concentration affects binding kinetics at very low and very high concentrations.
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