Describe and explain the serum protein profile of patients with suspected myeloma, as seen using non-denaturing polyacrylamide gel electrophoresis.
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Describe and explain the serum protein profile of patients with suspected myeloma, as seen using non-denaturing polyacrylamide gel electrophoresis.
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- Define Blue/White Screening. Explain principle mechanism of this approach briefly.State the principle of the antiglobulin test. Differentiate monoclonal from polyclonal and monospecific from polyspecific antihuman globulin (AHG) reagents.What are the sources of error in the Acid Hematin Method? Factors involved in the difference between oxyhemoglobin values and cyanmethemoglobin values in normal individuals.
- What additional biomarkers could be used to increase the specificity and sensitivity of DIC diagnosis. Give some examples and discuss their limitationsI understand that microarrays are being used to define the molecular abnormality and the prognosis in some patients with leukaemia. What are microarrays?What level of RF in serum is clinically significant? Why is a 1:20 dilution of patient serum, rather than undiluted patient serum, used for the qualitative test? Describe how the RF concentration is computed?
- 1)Which methods can be used for total protein determination? Please explain briefly. 2) Evaluate the total protein determination methods according to their sensitivity. 3) Explain for what purposes the determination of total protein is used.Discuss what are the current methods of diagnoising a pateint with microsystic anemia. Provide a detail for further possible diagonisitc testing, explain the diffrential diagosnies in detail give Full diffrential diagosni a detail step by step with examples.Explain how to administer an IM injection utilising the Z-track method.