David Seligson and his colleagues examined levels of histone proteinmodification in prostate tumors and their association with clinicaloutcomes (D. B. Seligson et al. 2005. Nature 435:1262–1266). Theyused antibodies to stain for acetylation at three different sites and formethylation at two different sites on histone proteins. They found that the degree of histone acetylation and methylation helped predict whetherprostate cancer would return within 10 years in the patients who had aprostate tumor removed. Explain how acetylation and methylation mightbe associated with tumor recurrence in prostate cancer.
David Seligson and his colleagues examined levels of histone proteinmodification in prostate tumors and their association with clinicaloutcomes (D. B. Seligson et al. 2005. Nature 435:1262–1266). Theyused antibodies to stain for acetylation at three different sites and formethylation at two different sites on histone proteins. They found that the degree of histone acetylation and methylation helped predict whetherprostate cancer would return within 10 years in the patients who had aprostate tumor removed. Explain how acetylation and methylation mightbe associated with tumor recurrence in prostate cancer.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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David Seligson and his colleagues examined levels of histone protein
modification in prostate tumors and their association with clinical
outcomes (D. B. Seligson et al. 2005. Nature 435:1262–1266). They
used antibodies to stain for acetylation at three different sites and for
methylation at two different sites on histone proteins. They found that
the degree of histone acetylation and methylation helped predict whether
prostate cancer would return within 10 years in the patients who had a
prostate tumor removed. Explain how acetylation and methylation might
be associated with tumor recurrence in prostate cancer.
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