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An experiment is carried out as depicted in Figure 1. Two drugs, staurosporine and camptothecin, are used to treat normal and cancer cells. Staurosporine is an inhibitor of protein kinases and can induce apoptosis by an undetermined mechanism. Camptothecin is known to inhibit the DNA topoisomerase type I. Discuss and conclude the effects of the drugs on the two different types of cells in this experiment. Normal cells Cancer cells 1. Add staurosporine 1. Add staurosporine Cells are arrested at restriction point Cells are arrested at restriction point 2. Add camptothecin 2. Add camptothecin Figure 1 Cells are arrested at restriction point Cells are killed when they pass through S phase 3. Remove Cell cycle both drugs resumes Dead cells

An experiment is carried out as depicted in Figure 1. Two drugs, staurosporine and camptothecin, are used to treat normal and cancer cells. Staurosporine is an inhibitor of protein kinases and can induce apoptosis by an undetermined mechanism. Camptothecin is known to inhibit the DNA topoisomerase type I. Discuss and conclude the effects of the drugs on the two different types of cells in this experiment. Normal cells Cancer cells 1. Add staurosporine 1. Add staurosporine Cells are arrested at restriction point Cells are arrested at restriction point 2. Add camptothecin 2. Add camptothecin Figure 1 Cells are arrested at restriction point Cells are killed when they pass through S phase 3. Remove Cell cycle both drugs resumes Dead cells

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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An experiment is carried out as depicted in Figure 1. Two drugs, staurosporine and camptothecin, are used to treat normal and cancer cells. Staurosporine is an inhibitor of protein kinases and can induce apoptosis by an undetermined mechanism. Camptothecin is known to inhibit the DNA topoisomerase type I. Discuss and conclude the effects of the drugs on the two different types of cells in this experiment. Normal cells Cancer cells 1. Add staurosporine 1. Add staurosporine Cells are arrested at restriction point Cells are arrested at restriction point 2. Add camptothecin 2. Add camptothecin Figure 1 Cells are arrested at restriction point Cells are killed when they pass through S phase 3. Remove both drugs Cell cycle resumes Dead cells
Transcribed Image Text:An experiment is carried out as depicted in Figure 1. Two drugs, staurosporine and camptothecin, are used to treat normal and cancer cells. Staurosporine is an inhibitor of protein kinases and can induce apoptosis by an undetermined mechanism. Camptothecin is known to inhibit the DNA topoisomerase type I. Discuss and conclude the effects of the drugs on the two different types of cells in this experiment. Normal cells Cancer cells 1. Add staurosporine 1. Add staurosporine Cells are arrested at restriction point Cells are arrested at restriction point 2. Add camptothecin 2. Add camptothecin Figure 1 Cells are arrested at restriction point Cells are killed when they pass through S phase 3. Remove both drugs Cell cycle resumes Dead cells
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