A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume of distribution 18 L. Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6 mg/L for 8 hours. What is the initial plasma concentration? (C) What is half life of this drug? (t1/2) Please select one: a.C-16.5 mg/L t1/2=5 h b.C=14 mg/L 11/2=2.5 h c.C=17.5 mg/L 11/2=3 h d.C=20.6 mg/L t1/2=5 h e.C=18.4 mg/L 11/2=5 h
A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume of distribution 18 L. Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6 mg/L for 8 hours. What is the initial plasma concentration? (C) What is half life of this drug? (t1/2) Please select one: a.C-16.5 mg/L t1/2=5 h b.C=14 mg/L 11/2=2.5 h c.C=17.5 mg/L 11/2=3 h d.C=20.6 mg/L t1/2=5 h e.C=18.4 mg/L 11/2=5 h
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Transcribed Image Text:A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume
of distribution 18 L.
• Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6
mg/L for 8 hours. What is the initial plasma concentration? (C)
• What is half life of this drug? (t1/2)
Please select one:
a.C-16.5 mg/L t1/2=5 h
b.C=14 mg/L 11/2=2.5 h
c.C=17.5 mg/L 11/2=3 h
d.C=20.6 mg/L t1/2=5 h
e.C-18.4 mg/L t1/2=5 h
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