Please answer asap O Farmesylation, a post translational modification required to localise Lamin to the nuclear lamina is missing in HGPS.Accelerated ageing seen in HGPS is as á result of conformational stress on DNA cause by increased p53 expressionarising from removal of a farnesyl group by an endopeptidase ZMPSTE24A 50 amino acid span of the polypeptide is deleted in mutant Pre-Lamin A which undergoes aberrant splicing resultingin progerinIn HGPS. progerin is longer due to containing a farnesyl group, arising as a result of mutations in farnesyl transferase. Hutchinson-Gilford Progeria Syndrome (HGPS) arises due to a mutation in Lamin A. Which is the following is MOST correctregarding the processing of Pre-Lamin A in ProgeriaMulhiple ChoiceFornesylation, a post translational modification required to localise Lamin to the nuclear lamina is missing in HGPS.O Accelerated ageing seen in HGPS is as a result of conformational stress on DNA couse by increosed p53 expressionarising from removal of e farnesyl group by an endopeptidase ZMPSTE24A 50 emino acid span of the polypeptide is deleted in mutant Pre-Lamin A which undergoes aberrant splicing resultingin progerin

Hutchinson-Gilford progeria syndrome or progeria is caused by a spontaneous point mutation in the…

Answered: A 50 amino acid span of the polypeptide…

A 50 amino acid span of the polypeptide is deleted in mutant Pre-Lamin A which undergoes aberrant splicing resulting in progerin

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter13: Gene Expression

Section: Chapter Questions

Problem 12TYU

See similar textbooks

Related questions

Q: Surgical instruments are cleaned by heating them. Alcohol is used as disinfectant in cleansing the…

A: The most efficient method of sterilizing surgical instruments is Intense heat provided they can…

Q: Two human parents with dimples have children and they all do not have dimples. What are the…

A: Dimples are dominant traits. Dominant traits arise from those alleles (dominant) which are always…

Q: 4. Sickle cell anemia occurs due to a point mutation in a gene for hemoglobin protein. This mutation…

A: The question is asked to fill the table. In sickle cell anemia, there is single nucleotide change…

Q: Your science teacher says that matter is conserved in the process of cellular respiration. What…

A: Cellular respiration is a process in which glucose and oxygen molecules react to produce water,…

Q: True or False: Neurotransmitters have different shapes.

Q: Predict the outcome of an error in ELISA protocol consisting of adding the antibodies in the wrong…

A: ELISA stands for enzyme linked immunosorbant assay.This techniques is basically used for the…

Q: Discuss viral strategies to evolute new flu virus following the given picture Re-emergence of…

A: "Antigenic drift" and "antigenic shift" are terms used to describe how influenza A viruses change…

Q: Why is important to have several receptors in an aquatic environment? Considering all you have…

A: Anatomy, which reveals that evolutionary ties may be proven through homologous structures, and…

Q: In your view what motivates youngsters to take to alcohol or drugs and how can this be avoided?

A: There are a variety of factors that influence young people's decision to consume alcohol. A few…

Q: Question 19 Listen Aminoacyl-tRNA synthase recognizes their specific amino acid by and A ; they…

A: Aminoacyl tRNA synthase is also known as tRNA ligase. It loads or charge the tRNA with specific…

Q: best friend, who is a curator at a Natural History Museum calls you up one day to ask for your help…

Q: If acetylcholine re-uptake is blocked in the synaptic cleft, then what happens in the muscle cell?…

A: "Muscle contraction" is responsible for every movement in our bodies and may be found in every…

Q: Suppose that a plant cell membrane is permeable with Na*, CI ions and H20, but not with proteins. In…

A: THE FORMULA FOR FINDING THEFT POTENTIAL is: EION= RTNFlnIONOUTIONINWHERE R-UNIVERSAL GAS CONSTANT…

Q: Eukaryotic cells have extensive intra-cellular compartments. Compartmentalization has evolved in…

A: Amount of time required for an ATP molecule to diffuse across a human cell :-

Q: Calculate the allelic frequencies observed in the class for marker PV92. Is the class 'population'…

A: Key points: Microevolution is a change in the frequency of gene variants, alleles, in a…

Q: What are mitochondria?

A: Mitochondria (sing. Mitochondrion) are the membrane bound organelles found in the cells. they are…

Q: The difference between a linking number in a relaxed state vs supercoiled state?

A: A "nucleic acid" is a linear polymer of nucleotides that is a component of the cell's information…

Q: We have studied how the six major primate groups evolved, with the most recent group being the…

A: Early people had been nonetheless swinging from timber two million years ago, scientists have said,…

Q: I Need help understanding & explaing The Virulenece Involving TB .. What are Virulence Factors of…

A: Introduction Virulence is described as an ability of an organism to infect or damage its host…

Q: Explain pulmonary and Aortic circulation in man.

A: Introduction The circulatory system is the system that contains the heart and the blood vessels…

Q: Q:-Do you think microbes can also be used as a source of energy? If yes, how?

A: Yes, microbes can be used as a source of energy. Bacteria such as Methane bacterium is used for the…

Q: what are ways you can run a PCR cycle in a single test tube? how would you adjust amplificons,…

A: Applications of PCR: For DNA fingerprinting, to identify an individual from blood or tissue left at…

Q: What is autonomous specifications

A: One of the aims of embryology is to comprehend how a cell grows into a certain cell type, a process…

Q: What are the differences between the life cycle of Symbion Pandora and Plasmodium (commonly known as…

A: Symbian Pandora and Plasmodium species,both can cause malaria, hence known as malarial parasites.

Q: Microbes can provide beneficial activities. Bioremediation (using bacteria) is a process used to…

A: Microbes, such as bacteria and fungus, are minute single-celled organisms. Most microorganisms are…

Q: Find out the role of microbes in the following (a) Single cell protein (SCP)

A: Introduction Microbes are tiny living things that are found all around us, they are unicellular…

Q: 28. What are the morphological, chemical and functional similarities and differences between…

A: Here I will discuss the morphological, chemical, and functional similarities and differences between…

Q: I want to do a manual white blood cell differential count on this photo. I just need help with…

A: White blood cells are one of the types of blood cells including red blood cells and blood platelets.…

Q: Show a picture or draw Of Rice plant with the pest repellent property of Basil leaves (3d Model)

A: The Plant Kingdom is extremely valuable to humanity as a resource. Humans would be unable to exist…

Q: Illustrate the life histories of the parasites Trypanosoma brucei rhodesiense and Plasmodium vivax.…

A: All parasites have a lifestyles cycle that includes a time period spent in a host organism and that…

Q: The sum of the lengths of DNA fragments 1-3 equal the total original length? True / False

A: Answer : The sum of the lengths of DNA fragments 1-3 equal the total original length : false.

Q: the bald eagle protection act and its importance

A: The Bald and Golden Eagle Protection Act (16 U.S.C. 668-668d) is a United States federal statute…

Q: Evaluate factors that can determine why only a proportion of hosts within a species, and/or only…

A: There are so many parasites. Some parasites remain on the surface of the host and some parasites may…

Q: All of the following are true regarding the descending motor tracts EXCEPT which one? A. They…

A: The correct option is B.

Q: What is apiculture? How is it important in our lives?

A: Apiculture is the practise of keeping and rearing honey bees (Apis indica) in order to produce…

Q: Choose all that are false when considering the adaptive response to tan. a) The ability to tan…

A: Choose all that are false when considering the adaptive response to tan. Ans : b) It is a cellular…

Q: 19- The name of this organism is: A. Penicillium B. Glomus C. Saccharomyces…

A: The picture shows the budding. Budding is a type of an asexual reproduction which takes place in…

Q: Compare and contrast the advantages and disadvantages of production of genetically modified crops.

A: GM is a process that involves inserting DNA into the genome of an organism. To make a GM plant, new…

Q: A 2911 B teenot o slen bnuo bis >how Tien 32. A certain type of lens changes the direction of light…

A: Ans . The correct answer for the above question is E) POLARISATION. POLARISATION - restriction of…

Q: Suppose histones had a high percentage of negatively charged amino acids. What do you predict would…

A: Histones are the packaging proteins that bind to DNA.

Q: What is the path followed by the energy absorbed by plants to be used in photosynthesis?

A: Plants are classified as autotrophs because they can use light energy to make food. Many people…

Q: 8. An infarct involving the hypothalamus would most likely result from occlusion of which artery? A.…

A: The correct option is C.

Q: Question A virion is a single virus particle outside of a cell. It contains genetic material in the…

A: Answer : genes a virion contains are : 5 150 A virion has enough genetic information to code…

Q: Туре of Medium Original Color Negative Result Any Chemicals Added to Visualize Reaction? Positive…

A: *NOTE: Kindly repost for other question. Dear Student as per the guidelines we are supposed to…

Q: Which of the following is NOT a biological community? all of the students at an elementary school O…

Q: Which of the following would NOT increase the "indirect fitness" of an individual? Genetic relatives…

A: "Genes" are the fundamental unit of heredity. They store genetic information in the form of DNA,…

Q: Describe the mechanism of SERS( Surface Enhanced Raman Spectroscopy).

A: Introduction: Surface-enhanced Raman spectroscopy (SERS) is a strong microscopic observation…

Q: What are some organizations doing to prevent the spread of malaria?

A: The Malarial parasite, Plasmodium vivax belonging to the Genus, Plasmodium, possess a life cycle…

Q: Compare and contrast the processes of cell cycle and apoptosis and give an example of a drug or…

A: * cell cycle cell shows a series of events which takes place in a cell as it divides and grows. *A…

Q: Question 1: A. In Northern blotting, electrophoresis is used to resolve which biological molecules?…

A: * Northern blot is a laboratory method to detect RNA molecules in a mixture of RNA. *It is used to…

Concept explainers

Reproductive system infection

The biological process through which parents produce new children is called reproduction. A reproductive system is a group of internal and external organs that collaborate to allow males and females to reproduce. Many experts believe that the reproductive system is one of the most important systems in the body due to its crucial function in the survival of the species. Among the body's basic systems, the reproductive tract is the one that differs the most between sexes, and it is also the only one that does not operate until puberty.

Question

Please answer asap

O Farmesylation, a post translational modification required to localise Lamin to the nuclear lamina is missing in HGPS.
Accelerated ageing seen in HGPS is as á result of conformational stress on DNA cause by increased p53 expression
arising from removal of a farnesyl group by an endopeptidase ZMPSTE24
A 50 amino acid span of the polypeptide is deleted in mutant Pre-Lamin A which undergoes aberrant splicing resulting
in progerin
In HGPS. progerin is longer due to containing a farnesyl group, arising as a result of mutations in farnesyl transferase.

Hutchinson-Gilford Progeria Syndrome (HGPS) arises due to a mutation in Lamin A. Which is the following is MOST correct
regarding the processing of Pre-Lamin A in Progeria
Mulhiple Choice
Fornesylation, a post translational modification required to localise Lamin to the nuclear lamina is missing in HGPS.
O Accelerated ageing seen in HGPS is as a result of conformational stress on DNA couse by increosed p53 expression
arising from removal of e farnesyl group by an endopeptidase ZMPSTE24
A 50 emino acid span of the polypeptide is deleted in mutant Pre-Lamin A which undergoes aberrant splicing resulting
in progerin

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

Explain why energy is NOT needed for co-translational translocation but IS needed for post-translational ER translocation of an ER lumenal protein.
The tumor suppressor pRB also binds to and suppresses theactivity of retinoblastoma binding protein 2 (RBP2), ahistone demethylase that removes methyl groups from diand trimethylated lysines in histone 3. What is the possibleconsequence of an inactivating mutation in RB1 that causesan inability of pRB to bind RBP2?
Cytosine deaminationoccurs ~100 cytosinesper genome per day in a human genome. Eukaryotic cells also contain residues of 5’-methylcytosine, which is involved in regulating gene transcription rates. Mutation of 5’-methylcytosine by deaminationconverts it to thymine. This presents the cell with a much more severe problem than normal cytosine deaminationof cytosine to uracil. Why?
Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependent manner. By comparison, many other proteins do interact with nucleic acids in a sequence-dependent fashion. This means that a specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria.What information do you know based onthe question…
Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependentmanner. By comparison, many other proteins do interactwith nucleic acids in a sequence-dependent fashion. This means that a specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria.What topic in genetics does this question address?
Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependentmanner. By comparison, many other proteins do interactwith nucleic acids in a sequence-dependent fashion. This means thata specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria. With regard to the three-dimensional structure of…
TRUE FALSE EF-Ts factor regenerates EF-Tu/GDP from EF-Tu/GTP for the next round of elongation cycle in prokaryotic translation. The sigma o subunit of RNA polymerase is replaced by NusA to recognise the promoter region of a gene. The -10 and -35 sequences in E. coli DNA are referred to as untranslated region. In human, translation begins before transcription of an mRNA completes. The distal histidine stabilises the iron in heme group of a deoxyhaemoglobin. Receptor for epinephrine consists of seven transmembrane helices. Membrane receptors bind to hydrophobic signaling molecules. Amino acids, glucose and fatty acids are taken up by transporters into liver cells. Glycerol and fatty acids are synthesized from the intermediates of glycolysis. Synthesis of fatty acid occurs in cytoplasm. Triacylglycerol can be obtained from diet and also synthesized in liver cells. Ammonia and keto acid are formed in transamination.
Suppose that in the formation of phenylalanine hydroxylase mRNA, the exons of the pre-mRNA fail to splice together properly and the resulting enzyme is nonfunctional. This produces an accumulation of high levels of phenylalanine and other compounds, which causes neurological damage. What phenotype would be produced in the affected individual?
The following is a portion of a protein: met-trp-tyr-arg-gly-pro-thr-Various mutant forms of this protein have been recovered. Using the normal and mutant sequences, determine the DNA and mRNA sequences that code for this portion of the protein, and explain each of the mutations. a. met-trp- b. met-cys-ile-val-val-leu-gln- c. met-trp-tyr-arg-ser-pro-thr- d. met-trp-tyr-arg-gly-ala-val-ile-ser-pro-thr-
The Events in Transcription Initiation Describe the sequence of events involved in the initiation of transcription by E. coil RNA polymerase. Include in your description those features a gene must have for proper recognition and transcription by RNA poIymerase.
Several genes code for enzymes that are responsible for histidine biosynthesis in Escherichia coli. Part of the nucleotide sequence of the gene that codes for one of these enzymes is: AUG CCU UGG GCC CAA AAA UGC A series of mutants that have lost activity for this enzyme are recovered. The mutant products are analyzed and found to have the following amino acid sequences: Mutant 1: Met-Pro-Trp-Pro-Glu-Lys-Cys Mutant 2: Met-Pro Mutant 3: Met-Pro-Cys-Gly-Pro-Lys-Met Mutant 4: Met-Pro-Trp-Pro-Lys-Asp Choose the correct type of mutation that occurred in the DNA to produce each mutant type. Nonsense Answer Missense Answer Addition Answer Deletion Answer
During translation, the tRNA antlicodon sequence G-A-U vyould blnd to which MRNA codon (plck one of the cholces I -V below)? Note: all of the sequencos for tho quostlon and answors use the standard convention for representing ollgonuclootidos discussed In class whoro tho 5'-ond Is at the loft and the 3'-ond Is at the right. I) G-A-U II) U-A-G I) C-U-A IV) A-U-C V A-T-C OA. none of the cholces OB. IV Oc." OD.! OE, II